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Molecular pathology makes use of estimates of tumor content (tumor percentage) for pre-analytic and analytic purposes, such as molecular oncology testing, massive parallel sequencing, or next-generation sequencing (NGS), assessment of sample acceptability, accurate quantitation of variants, assessment of copy number changes (among other applications), determination of specimen viability for testing

Molecular pathology makes use of estimates of tumor content (tumor percentage) for pre-analytic and analytic purposes, such as molecular oncology testing, massive parallel sequencing, or next-generation sequencing (NGS), assessment of sample acceptability, accurate quantitation of variants, assessment of copy number changes (among other applications), determination of specimen viability for testing (since many assays require a minimum tumor content to report variants at the limit of detection) may all be improved with more accurate and reproducible estimates of tumor content. Currently, tumor percentages of samples submitted for molecular testing are estimated by visual examination of Hematoxylin and Eosin (H&E) stained tissue slides under the microscope by pathologists. These estimations can be automated, expedited, and rendered more accurate by applying machine learning methods on digital whole slide images (WSI).

ContributorsCirelli, Claire (Author) / Yang, Yezhou (Thesis director) / Yalim, Jason (Committee member) / Velu, Priya (Committee member) / Barrett, The Honors College (Contributor) / Computer Science and Engineering Program (Contributor)
Created2022-05
Description

This research paper explores the effects of data variance on the quality of Artificial Intelligence image generation models and the impact on a viewer's perception of the generated images. The study examines how the quality and accuracy of the images produced by these models are influenced by factors such as

This research paper explores the effects of data variance on the quality of Artificial Intelligence image generation models and the impact on a viewer's perception of the generated images. The study examines how the quality and accuracy of the images produced by these models are influenced by factors such as size, labeling, and format of the training data. The findings suggest that reducing the training dataset size can lead to a decrease in image coherence, indicating that AI models get worse as the training dataset gets smaller. Moreover, the study makes surprising discoveries regarding AI image generation models that are trained on highly varied datasets. In addition, the study involves a survey in which people were asked to rate the subjective realism of the generated images on a scale ranging from 1 to 5 as well as sorting the images into their respective classes. The findings of this study emphasize the importance of considering dataset variance and size as a critical aspect of improving image generation models as well as the implications of using AI technology in the future.

ContributorsPunyamurthula, Rushil (Author) / Carter, Lynn (Thesis director) / Sarmento, Rick (Committee member) / Barrett, The Honors College (Contributor) / School of Sustainability (Contributor) / Computer Science and Engineering Program (Contributor)
Created2023-05
Description

Breast cancer is one of the most common types of cancer worldwide. Early detection and diagnosis are crucial for improving the chances of successful treatment and survival. In this thesis, many different machine learning algorithms were evaluated and compared to predict breast cancer malignancy from diagnostic features extracted from digitized

Breast cancer is one of the most common types of cancer worldwide. Early detection and diagnosis are crucial for improving the chances of successful treatment and survival. In this thesis, many different machine learning algorithms were evaluated and compared to predict breast cancer malignancy from diagnostic features extracted from digitized images of breast tissue samples, called fine-needle aspirates. Breast cancer diagnosis typically involves a combination of mammography, ultrasound, and biopsy. However, machine learning algorithms can assist in the detection and diagnosis of breast cancer by analyzing large amounts of data and identifying patterns that may not be discernible to the human eye. By using these algorithms, healthcare professionals can potentially detect breast cancer at an earlier stage, leading to more effective treatment and better patient outcomes. The results showed that the gradient boosting classifier performed the best, achieving an accuracy of 96% on the test set. This indicates that this algorithm can be a useful tool for healthcare professionals in the early detection and diagnosis of breast cancer, potentially leading to improved patient outcomes.

ContributorsMallya, Aatmik (Author) / De Luca, Gennaro (Thesis director) / Chen, Yinong (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Computer Science and Engineering Program (Contributor)
Created2023-05
Description
This thesis investigates the quality and usefulness of "DeepDEMs" from Moon and Mars images, which are Digital Elevation Models (DEMs) created using deep learning from single optical images. High-resolution DEMs of Moon and Mars are increasingly critical for gaining insights into the slope and the elevation of the terrain in

This thesis investigates the quality and usefulness of "DeepDEMs" from Moon and Mars images, which are Digital Elevation Models (DEMs) created using deep learning from single optical images. High-resolution DEMs of Moon and Mars are increasingly critical for gaining insights into the slope and the elevation of the terrain in the region which helps in identifying the landing sites of possible manned missions and rovers. However, many locations of interest to scientists who use remote sensing to study the Earth or other planetary bodies have only visible image data coverage, and not repeated stereo image coverage or other data collected specifically for DEM generation. Thus, Earth and planetary scientists, geographers, and other academics want DEMs in many locations where no data resources (repeat coverage or intensive remote sensing campaigns) have been assigned for geomorphic or topographic study. One specific use for deep learning-generated terrain models would be to assess probable sites in the lunar south polar area for NASA's future Artemis III mission which aims to return people to the lunar surface. While conventional techniques (for example, needing two stereo pictures from satellites for photogrammetry) work well, this high-resolution data only covers a small portion of the planets. Furthermore, older approaches need lengthy processing durations as well as human calibration and tweaking to achieve high-quality DEMs. To address the coverage and processing time concerns, we evaluated deep learning algorithms for creating DEMs of the Moon and Mars' surfaces. We explore how the findings of this study may be used to create elevation models for planetary mapping in the future using automated methods.
ContributorsJain, Rini (Author) / Rastogi, Anant (Co-author) / Kerner, Hannah (Thesis director) / Adler, Jacob (Committee member) / Barrett, The Honors College (Contributor) / Computer Science and Engineering Program (Contributor) / Department of Information Systems (Contributor)
Created2024-05
Description
As the use of Artificial Intelligence (AI) continues to expand and improve across numerous industries, the success with which it has been integrated into the medical sector stands out. Physicians and researchers now utilize AI in many situations. In particular, advancements within the field of detection AI have had a

As the use of Artificial Intelligence (AI) continues to expand and improve across numerous industries, the success with which it has been integrated into the medical sector stands out. Physicians and researchers now utilize AI in many situations. In particular, advancements within the field of detection AI have had a significant impact on the diagnosis and treatment of scoliosis. Detection AI has been developed to recognize important features within an image, such as malignant tumors in adults. For a scoliosis patient, a detection model can manipulate radiograph images to create masks and highlight important features that could be missed by the human eye, such as minute changes in a cell, and create binary masks of a spine. Using a popular convolution neural network (CNN) to examine datasets of scoliosis x-rays, provided by Hanger Inc [6], this paper examines the capabilities of machine learning to effectively differentiate the spine from other bones in x-ray imagery and to identify scoliosis in affected patients. Based on the results of the project, several issues were discovered that, if resolved, could improve the overall accuracy of the model, which would allow it to potentially find its own place within medical workflows to expedite the scoliosis design process.
ContributorsCooney, Sloan (Author) / Kerner, Hannah (Thesis director) / Clark, Geoffrey (Committee member) / Barrett, The Honors College (Contributor) / Computer Science and Engineering Program (Contributor)
Created2024-05
Description
This paper presents work that was done to create a system capable of facial expression recognition (FER) using deep convolutional neural networks (CNNs) and test multiple configurations and methods. CNNs are able to extract powerful information about an image using multiple layers of generic feature detectors. The extracted information can

This paper presents work that was done to create a system capable of facial expression recognition (FER) using deep convolutional neural networks (CNNs) and test multiple configurations and methods. CNNs are able to extract powerful information about an image using multiple layers of generic feature detectors. The extracted information can be used to understand the image better through recognizing different features present within the image. Deep CNNs, however, require training sets that can be larger than a million pictures in order to fine tune their feature detectors. For the case of facial expression datasets, none of these large datasets are available. Due to this limited availability of data required to train a new CNN, the idea of using naïve domain adaptation is explored. Instead of creating and using a new CNN trained specifically to extract features related to FER, a previously trained CNN originally trained for another computer vision task is used. Work for this research involved creating a system that can run a CNN, can extract feature vectors from the CNN, and can classify these extracted features. Once this system was built, different aspects of the system were tested and tuned. These aspects include the pre-trained CNN that was used, the layer from which features were extracted, normalization used on input images, and training data for the classifier. Once properly tuned, the created system returned results more accurate than previous attempts on facial expression recognition. Based on these positive results, naïve domain adaptation is shown to successfully leverage advantages of deep CNNs for facial expression recognition.
ContributorsEusebio, Jose Miguel Ang (Author) / Panchanathan, Sethuraman (Thesis director) / McDaniel, Troy (Committee member) / Venkateswara, Hemanth (Committee member) / Computer Science and Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Machine learning models convert raw data in the form of video, images, audio,

text, etc. into feature representations that are convenient for computational process-

ing. Deep neural networks have proven to be very efficient feature extractors for a

variety of machine learning tasks. Generative models based on deep neural networks

introduce constraints on the

Machine learning models convert raw data in the form of video, images, audio,

text, etc. into feature representations that are convenient for computational process-

ing. Deep neural networks have proven to be very efficient feature extractors for a

variety of machine learning tasks. Generative models based on deep neural networks

introduce constraints on the feature space to learn transferable and disentangled rep-

resentations. Transferable feature representations help in training machine learning

models that are robust across different distributions of data. For example, with the

application of transferable features in domain adaptation, models trained on a source

distribution can be applied to a data from a target distribution even though the dis-

tributions may be different. In style transfer and image-to-image translation, disen-

tangled representations allow for the separation of style and content when translating

images.

This thesis examines learning transferable data representations in novel deep gen-

erative models. The Semi-Supervised Adversarial Translator (SAT) utilizes adversar-

ial methods and cross-domain weight sharing in a neural network to extract trans-

ferable representations. These transferable interpretations can then be decoded into

the original image or a similar image in another domain. The Explicit Disentangling

Network (EDN) utilizes generative methods to disentangle images into their core at-

tributes and then segments sets of related attributes. The EDN can separate these

attributes by controlling the ow of information using a novel combination of losses

and network architecture. This separation of attributes allows precise modi_cations

to speci_c components of the data representation, boosting the performance of ma-

chine learning tasks. The effectiveness of these models is evaluated across domain

adaptation, style transfer, and image-to-image translation tasks.
ContributorsEusebio, Jose Miguel Ang (Author) / Panchanathan, Sethuraman (Thesis advisor) / Davulcu, Hasan (Committee member) / Venkateswara, Hemanth (Committee member) / Arizona State University (Publisher)
Created2018
Description
The widespread adoption of computer vision models is often constrained by the issue of domain mismatch. Models that are trained with data belonging to one distribution, perform poorly when tested with data from a different distribution. Variations in vision based data can be attributed to the following reasons, viz., differences

The widespread adoption of computer vision models is often constrained by the issue of domain mismatch. Models that are trained with data belonging to one distribution, perform poorly when tested with data from a different distribution. Variations in vision based data can be attributed to the following reasons, viz., differences in image quality (resolution, brightness, occlusion and color), changes in camera perspective, dissimilar backgrounds and an inherent diversity of the samples themselves. Machine learning techniques like transfer learning are employed to adapt computational models across distributions. Domain adaptation is a special case of transfer learning, where knowledge from a source domain is transferred to a target domain in the form of learned models and efficient feature representations.

The dissertation outlines novel domain adaptation approaches across different feature spaces; (i) a linear Support Vector Machine model for domain alignment; (ii) a nonlinear kernel based approach that embeds domain-aligned data for enhanced classification; (iii) a hierarchical model implemented using deep learning, that estimates domain-aligned hash values for the source and target data, and (iv) a proposal for a feature selection technique to reduce cross-domain disparity. These adaptation procedures are tested and validated across a range of computer vision applications like object classification, facial expression recognition, digit recognition, and activity recognition. The dissertation also provides a unique perspective of domain adaptation literature from the point-of-view of linear, nonlinear and hierarchical feature spaces. The dissertation concludes with a discussion on the future directions for research that highlight the role of domain adaptation in an era of rapid advancements in artificial intelligence.
ContributorsDemakethepalli Venkateswara, Hemanth (Author) / Panchanathan, Sethuraman (Thesis advisor) / Li, Baoxin (Committee member) / Davulcu, Hasan (Committee member) / Ye, Jieping (Committee member) / Chakraborty, Shayok (Committee member) / Arizona State University (Publisher)
Created2017
Description
Humans have a great ability to recognize objects in different environments irrespective of their variations. However, the same does not apply to machine learning models which are unable to generalize to images of objects from different domains. The generalization of these models to new data is constrained by the domain

Humans have a great ability to recognize objects in different environments irrespective of their variations. However, the same does not apply to machine learning models which are unable to generalize to images of objects from different domains. The generalization of these models to new data is constrained by the domain gap. Many factors such as image background, image resolution, color, camera perspective and variations in the objects are responsible for the domain gap between the training data (source domain) and testing data (target domain). Domain adaptation algorithms aim to overcome the domain gap between the source and target domains and learn robust models that can perform well across both the domains.

This thesis provides solutions for the standard problem of unsupervised domain adaptation (UDA) and the more generic problem of generalized domain adaptation (GDA). The contributions of this thesis are as follows. (1) Certain and Consistent Domain Adaptation model for closed-set unsupervised domain adaptation by aligning the features of the source and target domain using deep neural networks. (2) A multi-adversarial deep learning model for generalized domain adaptation. (3) A gating model that detects out-of-distribution samples for generalized domain adaptation.

The models were tested across multiple computer vision datasets for domain adaptation.

The dissertation concludes with a discussion on the proposed approaches and future directions for research in closed set and generalized domain adaptation.
ContributorsNagabandi, Bhadrinath (Author) / Panchanathan, Sethuraman (Thesis advisor) / Venkateswara, Hemanth (Thesis advisor) / McDaniel, Troy (Committee member) / Arizona State University (Publisher)
Created2020
Description
Speech is known to serve as an early indicator of neurological decline, particularly in motor diseases. There is significant interest in developing automated, objective signal analytics that detect clinically-relevant changes and in evaluating these algorithms against the existing gold-standard: perceptual evaluation by trained speech and language pathologists. Hypernasality, the result

Speech is known to serve as an early indicator of neurological decline, particularly in motor diseases. There is significant interest in developing automated, objective signal analytics that detect clinically-relevant changes and in evaluating these algorithms against the existing gold-standard: perceptual evaluation by trained speech and language pathologists. Hypernasality, the result of poor control of the velopharyngeal flap---the soft palate regulating airflow between the oral and nasal cavities---is one such speech symptom of interest, as precise velopharyngeal control is difficult to achieve under neuromuscular disorders. However, a host of co-modulating variables give hypernasal speech a complex and highly variable acoustic signature, making it difficult for skilled clinicians to assess and for automated systems to evaluate. Previous work in rating hypernasality from speech relies on either engineered features based on statistical signal processing or machine learning models trained end-to-end on clinical ratings of disordered speech examples. Engineered features often fail to capture the complex acoustic patterns associated with hypernasality, while end-to-end methods tend to overfit to the small datasets on which they are trained. In this thesis, I present a set of acoustic features, models, and strategies for characterizing hypernasality in dysarthric speech that split the difference between these two approaches, with the aim of capturing the complex perceptual character of hypernasality without overfitting to the small datasets available. The features are based on acoustic models trained on a large corpus of healthy speech, integrating expert knowledge to capture known perceptual characteristics of hypernasal speech. They are then used in relatively simple linear models to predict clinician hypernasality scores. These simple models are robust, generalizing across diseases and outperforming comprehensive set of baselines in accuracy and correlation. This novel approach represents a new state-of-the-art in objective hypernasality assessment.
ContributorsSaxon, Michael Stephen (Author) / Berisha, Visar (Thesis advisor) / Panchanathan, Sethuraman (Thesis advisor) / Venkateswara, Hemanth (Committee member) / Arizona State University (Publisher)
Created2020