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Glioblastoma brain tumors are among the most lethal human cancers. Treatment efforts typically involve both surgical tumor removal, as well as ongoing therapy. In this work, we propose the use of deuterium magnetic resonance imaging (MRI) to delineate tumor boundaries based on spatial distributions of deuterated leucine, as well as

Glioblastoma brain tumors are among the most lethal human cancers. Treatment efforts typically involve both surgical tumor removal, as well as ongoing therapy. In this work, we propose the use of deuterium magnetic resonance imaging (MRI) to delineate tumor boundaries based on spatial distributions of deuterated leucine, as well as resolve the metabolism of leucine within the tumor. Accurate boundary identification contributes to effectiveness of tumor removal efforts, while amino acid metabolism information may help characterize tumor malignancy and guide ongoing treatment. So, we first examine the fundamental mechanisms of deuterium MRI. We then discuss the use of spin-echo and gradient recall echo sequences for mapping spatial distributions of deuterated leucine, and the use of single-voxel spectroscopy for imaging metabolites within a tumor.
ContributorsCostelle, Anna (Author) / Beeman, Scott (Thesis director) / Kodibagkar, Vikram (Committee member) / Barrett, The Honors College (Contributor) / Department of Physics (Contributor) / School of Mathematical and Statistical Sciences (Contributor)
Created2022-05
Description
My creative project is a Python program designed to simulate a $100,000 stock portfolio using real data about the stock market. It runs continuously on my computer and executes the main body of the code once per day at 11:00 am AZ time. It will pull prices from the internet

My creative project is a Python program designed to simulate a $100,000 stock portfolio using real data about the stock market. It runs continuously on my computer and executes the main body of the code once per day at 11:00 am AZ time. It will pull prices from the internet for all stocks in the S&P 500 between 07/01/2023 and now. Each day, the program outputs two .csv files showing the makeup of the portfolio and an aggregated list of all transactions that have taken place. The financial decisions are made using Modern Portfolio Theory and the Efficient Frontier model, balancing risk and maximizing the Sharpe ratio to create the most mathematically optimal portfolio. There is a lot of documentation available to users to show the process of the code through daily executions, how to install required packages, and ultimately how to use the program. It was designed as a simulation for this project but has the potential to be expanded beyond its current bounds and eventually become a legitimate algorithm trading bot.
ContributorsAmazeen, Andrew (Author) / Sopha, Matt (Thesis director) / Pruitt, Seth (Committee member) / Barrett, The Honors College (Contributor) / School of Accountancy (Contributor) / Department of Information Systems (Contributor)
Created2024-05
Description

This paper describes a project involving the optimization of the analysis process of FreeSurfer and ANTS Registration for neuroscience analytics of patients at risk of cognitive decline using Nipype. The paper details the process of discovering more about Nipype, learning to use a supercomputer, and implementing the open-source python code

This paper describes a project involving the optimization of the analysis process of FreeSurfer and ANTS Registration for neuroscience analytics of patients at risk of cognitive decline using Nipype. The paper details the process of discovering more about Nipype, learning to use a supercomputer, and implementing the open-source python code to fit the needs of the research lab. Nipype is a python-based initiative to unify the various software packages used within the neuroscience community for data analysis. This paper also serves as documentation of the steps taken to complete the project so that future students are able to continue the optimization process to result in one cohesive workflow in which data is able to flow through a unified pipeline of analysis in the future.

ContributorsCave, Elizabet (Author) / Ofori, Edward (Thesis director) / Sopha, Matthew (Committee member) / Barrett, The Honors College (Contributor) / Department of Information Systems (Contributor)
Created2023-05
Description

This paper explores the inner workings of algorithms that computers may use to play Chess. First, we discuss the classical Alpha-Beta algorithm and several improvements, including Quiescence Search, Transposition Tables, and more. Next, we examine the state-of-the-art Monte Carlo Tree Search algorithm and relevant optimizations. After that, we consider a

This paper explores the inner workings of algorithms that computers may use to play Chess. First, we discuss the classical Alpha-Beta algorithm and several improvements, including Quiescence Search, Transposition Tables, and more. Next, we examine the state-of-the-art Monte Carlo Tree Search algorithm and relevant optimizations. After that, we consider a recent algorithm that transforms Alpha-Beta into a “Rollout” search, blending it with Monte Carlo Tree Search under the rollout paradigm. We then discuss our C++ Chess Engine, Homura, and explain its implementation of a hybrid algorithm combining Alpha-Beta with MCTS. Finally, we show that Homura can play master-level Chess at a strength currently exceeding that of our backtracking Alpha-Beta.

ContributorsMoore, Evan (Author) / Kobayashi, Yoshihiro (Thesis director) / Kambhampati, Subbarao (Committee member) / Barrett, The Honors College (Contributor) / Computer Science and Engineering Program (Contributor)
Created2023-05
Description
This thesis addresses the impact of algorithmic programming on judicial decision-making and the court-appointed attorney (CAA) process, focusing on the intersection of technology and judicial discretion at the Tempe Municipal Court. The primary inquiry of this thesis explores how algorithmic and digital programming, creating an automated system, can enhance equitable

This thesis addresses the impact of algorithmic programming on judicial decision-making and the court-appointed attorney (CAA) process, focusing on the intersection of technology and judicial discretion at the Tempe Municipal Court. The primary inquiry of this thesis explores how algorithmic and digital programming, creating an automated system, can enhance equitable access to legal representation for indigent criminal defendants by making the CAA process more uniform. This project implements back-end algorithmic calculations to provide judges with system recommendations by using the Qualtrics survey software to create a digital version of the paper-based Form 5C. The "System Recommendation Tool" streamlines the process by presenting concise encapsulations of defendants' Form 5C responses and algorithmically derived recommendations regarding CAA qualification and contribution amounts. Significant disparities between the digital system's recommendations and judicial outcomes emerge through analyzing 80 Form 5Cs and their corresponding judicial decisions. These disparities underscore the need for further refinement of the digital system and the possibility of increased use of judicial discretion and consideration of additional factors beyond the Form 5C. While recognizing the system's potential benefits, this research emphasizes the importance of continuous testing and refinement and ongoing consultation with judges. Ultimately, the digital system is a complementary tool to judicial decision-making rather than a replacement.
ContributorsSharma, Poorva (Author) / Broberg, Gregory (Thesis director) / Kane, Kevin (Committee member) / Barrett, The Honors College (Contributor) / Dean, W.P. Carey School of Business (Contributor) / School of Social Transformation (Contributor)
Created2024-05
Description

This thesis examines the re-entry processes of individuals with mental health needs upon their release from prison. In order to uncover the resources that are provided to formerly incarcerated individuals with clinically diagnosed mental health issues, parole officers who have experience supervising individuals with mental health needs were interviewed. The

This thesis examines the re-entry processes of individuals with mental health needs upon their release from prison. In order to uncover the resources that are provided to formerly incarcerated individuals with clinically diagnosed mental health issues, parole officers who have experience supervising individuals with mental health needs were interviewed. The purpose of the interviews was to understand the experiences parole officers have regarding current supervision practices that are used, as well as programming and treatment opportunities parole officers know are available to this population of re-entrants. Being aware of the resources that are provided to formerly incarcerated individuals with mental health needs will help identify how to improve supervision, programming, and treatment so as to better support this population. As research and literature on the re-entry experiences of individuals with mental health care needs have demonstrated the extensive privations this population experiences, interviewing parole officers will reveal the roles parole officers, treatment providers, and programming have in supporting this population upon their release from prison. Moreover, interviewing parole officers will help identify how to improve parole outcomes for re-entrants with clinically diagnosed mental health issues.

ContributorsWalden, Hannah (Author) / Chamberlain, Alyssa (Thesis director) / Wright, Kevin (Committee member) / Barrett, The Honors College (Contributor) / Dean, W.P. Carey School of Business (Contributor) / School of Criminology and Criminal Justice (Contributor)
Created2021-12
Description

This creative project is an extension of the work being done as part of Senior Design in<br/>developing the See-Through Car Pillar, a system designed to render the forward car pillars in a car<br/>invisible to the driver so they can have an unobstructed view utilizing displays, sensors, and a<br/>computer. The first

This creative project is an extension of the work being done as part of Senior Design in<br/>developing the See-Through Car Pillar, a system designed to render the forward car pillars in a car<br/>invisible to the driver so they can have an unobstructed view utilizing displays, sensors, and a<br/>computer. The first half of the paper provides the motivation, design and progress of the project, <br/>while the latter half provides a literature survey on current automobile trends, the viability of the<br/>See-Through Car Pillar as a product in the market through case studies, and alternative designs and <br/>technologies that also might address the problem statement.

ContributorsRoy, Delwyn J (Author) / Thornton, Trevor (Thesis director) / Kozicki, Michael (Committee member) / Electrical Engineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

In this paper, I propose that taking an embodied approach to music performance can allow for better gestural control over the live sound produced and greater connection between the performer and their audience. I examine the many possibilities of live electronic manipulation of the voice such as those employed by

In this paper, I propose that taking an embodied approach to music performance can allow for better gestural control over the live sound produced and greater connection between the performer and their audience. I examine the many possibilities of live electronic manipulation of the voice such as those employed by past and current vocalists who specialize in live electronic sound manipulation and improvisation. Through extensive research and instrument design, I have sought to produce something that will benefit me in my performances as a vocalist and help me step out from the boundaries of traditional music performance. I will discuss the techniques used for the creation of my gestural instrument through the lens of my experiences as a performer using these tools. I believe that, through use of movement and gesture in the creation and control of sound, it is more than possible to step away from conventional ideas of live vocal performance and create something new and unique, especially through the inclusion of improvisation.

ContributorsEstes, Isabel (Author) / Hayes, Lauren (Thesis director) / Thorn, Seth (Committee member) / Barrett, The Honors College (Contributor) / Arts, Media and Engineering Sch T (Contributor)
Created2021-12
Description
The purpose of this experiment was to research using Virtual Reality (VR) as a way for a home builder to experience their unbuilt home, similarly to home shoppers experiencing built homes through open houses and tours. It discusses the ideas and technologies involved, the process for developing a home in

The purpose of this experiment was to research using Virtual Reality (VR) as a way for a home builder to experience their unbuilt home, similarly to home shoppers experiencing built homes through open houses and tours. It discusses the ideas and technologies involved, the process for developing a home in VR, and the observations found from demoing it to people. The research was started based on the "presence" effect in VR. Presence describes the feeling when the user is convinced that they are truly in the virtual world. The research conducted found that the main immersion creator and breaker is the interactivity capable in the virtual home. Through demoing a virtual home, it was discovered that the user was less sensitive to the visual quality of the house, and more sensitive to any inconsistent interactions with the house. If the user could physically open a door, but then not a drawer, they were shaken out of their presence. The research conducted also found that VR can provide enough immersion to make the home owner feel "present" in their new home if the application is built with a focus on consistent interactions throughout the environment. This application is capable of severely disrupting the current market climate and reshaping the way home builders decide what house they want to build.
ContributorsConigliari, Jason (Author) / Mazzola, Daniel (Thesis director) / Ahmad, Altaf (Committee member) / Department of Information Systems (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Programming is quickly becoming as ubiquitous a tool as general mathematics. The technology field is progressing at an exponential rate and driving this constantly evolving field forward requires competent software developers. Elementary and high school educational facilities do not currently express the importance of the computer science field. Computer science

Programming is quickly becoming as ubiquitous a tool as general mathematics. The technology field is progressing at an exponential rate and driving this constantly evolving field forward requires competent software developers. Elementary and high school educational facilities do not currently express the importance of the computer science field. Computer science is not a required course in high school and nearly impossible to find at a middle school level. This lack of exposure to the field at a young age handicaps aspiring developers by not providing them with a foundation to build on when seeking a degree. This paper revolves around the development of a virtual world that encompasses principles of programming in a video game structure. The use of a virtual world-based game was chosen under the hypothesis that embedding programming instruction into a game through problem-based learning is more likely to engage young students than more traditional forms of instruction. Unlike the traditional method of instruction, a virtual world allows us to "deceive" the player into learning concepts by implicitly educating them through fun gameplay mechanics. In order to make our video game robust and self-sufficient, we have developed a predictive recursive descent parser that will validate any user-generated solutions to pre-defined logical platforming puzzles. Programming topics taught with these problems range from binary numbers to while and for loops.
ContributorsWest, Grant (Co-author) / Kury, Nizar (Co-author) / Nelson, Brian (Thesis director) / Kobayashi, Yoshihiro (Committee member) / Computer Science and Engineering Program (Contributor) / Computing and Informatics Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12