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Description
Phytochromes are a family of photoreceptors that control light responses of plants, fungi and bacteria. A sequence of structural changes, which is not yet fully understood, leads to activation of an output domain. Time-resolved serial femtosecond crystallography (SFX) can potentially shine light on these conformational changes. Here we report the room temperature crystal structure of the chromophore-binding domains of the Deinococcus radiodurans phytochrome at 2.1 Å resolution. The structure was obtained by serial femtosecond X-ray crystallography from microcrystals at an X-ray free electron laser. We find overall good agreement compared to a crystal structure at 1.35 Å resolution derived from conventional crystallography at cryogenic temperatures, which we also report here. The thioether linkage between chromophore and protein is subject to positional ambiguity at the synchrotron, but is fully resolved with SFX. The study paves the way for time-resolved structural investigations of the phytochrome photocycle with time-resolved SFX.
ContributorsEdlund, Petra (Author) / Takala, Heikki (Author) / Claesson, Elin (Author) / Henry, Leocadie (Author) / Dods, Robert (Author) / Lehtivuori, Heli (Author) / Panman, Matthijs (Author) / Pande, Kanupriya (Author) / White, Thomas (Author) / Nakane, Takanori (Author) / Berntsson, Oskar (Author) / Gustavsson, Emil (Author) / Bath, Petra (Author) / Modi, Vaibhav (Author) / Roy Chowdhury, Shatabdi (Author) / Zook, James (Author) / Berntsen, Peter (Author) / Pandey, Suraj (Author) / Poudyal, Ishwor (Author) / Tenboer, Jason (Author) / Kupitz, Christopher (Author) / Barty, Anton (Author) / Fromme, Petra (Author) / Koralek, Jake D. (Author) / Tanaka, Tomoyuki (Author) / Spence, John (Author) / Liang, Mengning (Author) / Hunter, Mark S. (Author) / Boutet, Sebastien (Author) / Nango, Eriko (Author) / Moffat, Keith (Author) / Groenhof, Gerrit (Author) / Ihalainen, Janne (Author) / Stojkovic, Emina A. (Author) / Schmidt, Marius (Author) / Westenhoff, Sebastian (Author) / College of Liberal Arts and Sciences (Contributor) / School of Molecular Sciences (Contributor) / Biodesign Institute (Contributor) / Applied Structural Discovery (Contributor) / Department of Physics (Contributor)
Created2016-10-19
Description
Tales from the Amusement Park is a collection of songs in the musical theatre style with music and lyrics by Matt Villar. The song cycle illustrates a series of vignettes, with each song featuring a different archetypal character (or group thereof) as they navigate a day in a popular amusement park. The project is written for piano and voices, and is most-suited to twelve or fewer voices. The debut performance occurred on March 26 in the Evelyn Smith Music Theatre, and featured twelve singers and one pianist. The cycle aims to connect the audience through the demonstration of "human moments" which are widely relatable, while also introducing them to unique and interesting characters.
ContributorsVillar, Matthew (Author) / DeMaris, Brian (Thesis director) / Chin, Michelle (Committee member) / Yatso, Toby (Committee member) / Barrett, The Honors College (Contributor) / School of Music, Dance and Theatre (Contributor)
Created2023-05
ContributorsDi Russo, Michelle (Conductor) / Alpizar, Mark (Conductor) / Shaker, Shannon (Conductor) / Gupta, Kamna (Conductor) / ASU Library. Music Library (Publisher)
Created2017-11-29
ContributorsPercussion Jazz Ensemble (Performer) / ASU Library. Music Library (Publisher)
Created2017-11-20
ContributorsSmith, J. B., 1957- (Director) / Mancuso, Simone (Director) / Contemporary Percussion Ensemble (Performer) / ASU Library. Music Library (Contributor)
Created2017-11-19
ContributorsSmith, Aaron (Performer) / Solari, John (Performer) / Hammond, Marinne (Performer) / Shaner, Hayden (Performer) / Kempton, Emily (Performer) / Wills, Grace (Performer) / Rumney, Emily (Performer) / Neff, Megyn (Performer) / DiBarry, Michael (Performer) / ASU Library. Music Library (Publisher)
Created2017-11-17
ContributorsWorld Percussion Ensemble (Performer) / ASU Library. Music Library (Publisher)
Created2017-11-14