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Sensorimotor adaptation is a type of learning that allows sustaining accurate movements by adjusting motor output. This allows the brain to adapt to temporary changes when engaged in a certain task. Within sensorimotor adaptation, visuomotor adaptation (VMA) is one’s ability to correct a visual perturbation. In this study, we present

Sensorimotor adaptation is a type of learning that allows sustaining accurate movements by adjusting motor output. This allows the brain to adapt to temporary changes when engaged in a certain task. Within sensorimotor adaptation, visuomotor adaptation (VMA) is one’s ability to correct a visual perturbation. In this study, we present preliminary results on the effects of VMA with the control group, compared to groups undergoing trigeminal nerve stimulation (TNS) or SHAM (placebo) effects. Twenty-two healthy subjects with no past medical history participated in this study. Subjects performed a visuomotor rotation task, which required gradually adapting to a perturbation between hand motion and corresponding visual feedback. Five total blocks were completed: two familiarization blocks, one baseline block, one rotation block with a 30◦ counterclockwise rotation, and one washout block with no rotation. The control group performed better than the 120 Hz (TNS) and SHAM groups due to less directional error (DE) on the respective learning curves. Additionally, the control group adapted faster (less DE) than the SHAM groups that either felt stimulation, or did not feel the stimulation. The results yield new information regarding VMA which can be used in the future when comparing sensorimotor adaptation and its many applications.

ContributorsBass, Trevor (Author) / Buneo, Christopher (Thesis director) / Helms Tillery, Stephen (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2023-05
Description
Endometriosis is a chronic inflammatory gynecological disease, characterized by endometrial tissue growing outside of the uterus in lesions. It is predominantly a women's disease but has been found in men in rare cases. There is not a known pathogenesis, although there are multiple theories. The most accepted is retrograde menstruation;

Endometriosis is a chronic inflammatory gynecological disease, characterized by endometrial tissue growing outside of the uterus in lesions. It is predominantly a women's disease but has been found in men in rare cases. There is not a known pathogenesis, although there are multiple theories. The most accepted is retrograde menstruation; however, there are limitations to the theory due to its inability to account for endometriosis in men and ectopic lesions. Currently, it is debated and unclear if endometriosis should be labeled as an autoimmune disease. The purpose of my project was to research specifically autoimmunity in relation to immune responses to endometriosis and its immune dysfunction to provide a recommendation as to whether it should be relabeled as an autoimmune disease. The main argument for why endometriosis is not an autoimmune disease is that immune cells are not primarily attacking the normal endometrial tissue self-antigens. Instead, due to immune dysfunction, there is reduced apoptosis of the endometrial cells shed during menstruation, leading to their persistence, migration and invasion into different tissues, and proliferation into lesions. The immune response to lesions leads to production of autoantibodies that recognize and attack the self-antigens of the endometrial cells in the lesions. The presence of autoantibodies against endometrial self-antigens would provide support for it being an autoimmune disease. Multiple factors of autoimmune diseases are also associated with endometriosis: increased likelihood of developing other autoimmune diseases, similar immune cell populations, imbalance in Th1 and Th2 lymphocytes, dysfunction of cell apoptosis, immune dysfunction, genetic contributors, high risk HLAs, autoantibodies, polyclonal B cell activation, and responsiveness to immunomodulatory treatments. Due to these factors and the immune system's ability to recognize and attack the self-antigens in the lesion, endometriosis should be considered an autoimmune disease.
ContributorsSpencer, Haleigh (Author) / Weaver, Jessica (Thesis director) / Mehta, Jinal (Committee member) / Barrett, The Honors College (Contributor) / School of Biological & Health Systems Engineering (Contributor) / Harrington Bioengineering Program (Contributor)
Created2024-05
Description
Current demographic and water use trends prompt concerns for increasing water scarcity. Water reuse and wastewater reuse can help accommodate for some of these concerns. One application of this wastewater reuse can come in the form of agricultural applications. This, however, raises concerns of human and environmental exposure to antibiotic

Current demographic and water use trends prompt concerns for increasing water scarcity. Water reuse and wastewater reuse can help accommodate for some of these concerns. One application of this wastewater reuse can come in the form of agricultural applications. This, however, raises concerns of human and environmental exposure to antibiotic resistance genes and bacteria (ARGs/ARBs). Organizations such as the Center for Disease Control and Prevention (CDC) and the World Health Organization (WHO) cite increasing exposure and cases of antibiotic resistant bacteria related infections. This has led to a need for a more thorough understanding of risk and risk management strategies for these purposes. Biosolids can be used as fertilizers after treatment from wastewater treatment plants and as a result may be a potential avenue for exposure. Biosolids are activated sludge commonly dewatered and/or further treated for agricultural applications and are a focus of this thesis. The objectives of this thesis are (1) to contribute to a literature review of ARGs in biosolids with a specific focus on the effects of different treatment practices; and (2) quantify E. coli bacteria, intI1 (an integron-integrase gene used as an indicator of anthropogenic pollution), some heavy metals, and nutrients (N, P, and K) for newly collected biosolids samples in a multifactorial-designed lettuce growth experiment. Results found that most data points did not report wastewater treatment type. Additionally, TH/TH-MAD appeared to have lower ARG concentrations relative to other treatment types. Organizations such as the U.S. Environmental Protection Agency (USEPA) and the WHO provide maximum permissible limits of certain contaminants in plants and soils. Results found Cadmium concentrations in lettuce to be above these outlined limits. E. coli bacteria and intI1 results varied. Ultimately, in the future there needs to be more consistent reporting guidelines for obtaining ARG/ARB data and developing risk models for assessing potential exposure.
ContributorsKuppravalli, Aditya (Author) / Hamilton, Kerry (Thesis director) / Conroy-Ben, Otakuye (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2024-05
Description

When behaving in a goal-directed manner, the ability to suppress specific inappropriate actions is crucial to human motor function. Motor inhibition, or the repression of specific actions prior to and during onset of a motor command, allows humans to quickly respond and adapt their decisions to unexpected changes within an

When behaving in a goal-directed manner, the ability to suppress specific inappropriate actions is crucial to human motor function. Motor inhibition, or the repression of specific actions prior to and during onset of a motor command, allows humans to quickly respond and adapt their decisions to unexpected changes within an environment. Research investigating the faciliatory effects of anodal transcranial direct current stimulation (tDCS), a non-invasive stimulation technique that can potentially modulate the activity of target regions of the brain, on inhibition have been well-documented in the use of conventional or 1x1 tDCS devices. However, the the advent of High-Definition tDCS (HD-tDCS), which is claimed to enhance spatial precision through the usage of multiple smaller electrodes, has led to increased interest in its effects on motor inhibition and related cognitive processes. HD-tDCS may offer a more targeted approach to modulating neural circuits involved in motor planning and inhibitory control, such as the pre-Supplementary Motor Area (pre-SMA) and dorsolateral prefrontal cortex (DLPFC). This study aims to investigate the effects of anodal HD-tDCS over the pre-SMA on motor inhibition using the stop-signal task. By examining response times, error rates, and Stop Signal Reaction Time (SSRT), we seek to understand the potential advantages of HD-tDCS in modulating motor-related cognitive processes. These findings have implications for refining brain stimulation techniques and developing targeted interventions for conditions involving impaired inhibitory control.

ContributorsGurram, Hitesh (Author) / Schaefer, Sydney (Thesis director) / Brewer, Gene (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2024-05
Description
This thesis investigates the association between respiratory & psychiatric conditions, and heat stress. The specific aim of this study determined whether heat-related illnesses (heat syncope, heat exhaustion, and heat stroke) significantly contribute to the number of psychiatric emergency and chronic obstructive pulmonary disorder emergency department visits for adults 70 years and older in

This thesis investigates the association between respiratory & psychiatric conditions, and heat stress. The specific aim of this study determined whether heat-related illnesses (heat syncope, heat exhaustion, and heat stroke) significantly contribute to the number of psychiatric emergency and chronic obstructive pulmonary disorder emergency department visits for adults 70 years and older in Arizona.
ContributorsSyed, Zain (Author) / Cortese, Denis (Thesis director) / Moseley, Pope (Committee member) / Landman, Natalie (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2024-05
Description
The primary goal of this project was to design a more accessible human powered vehicle for lower-limb amputees. This was done using a variety of engineering concepts within the fields of both biomedical and aerospace engineering. This report will provide a background on why it is essential to have such vehicles and detail

The primary goal of this project was to design a more accessible human powered vehicle for lower-limb amputees. This was done using a variety of engineering concepts within the fields of both biomedical and aerospace engineering. This report will provide a background on why it is essential to have such vehicles and detail the overall design process to describe how specific design decisions were made. The final design will then be analyzed and followed up with a brief discussion and conclusion to elaborate on future steps and summarize the project as a whole.
ContributorsJimenez, Nicholas (Author) / Magewick, Alexander (Co-author) / Sobrado, Michael (Thesis director) / LaZear, Gus (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2024-05
DescriptionThis project examines the relationship between population-level childhood lead exposure and the incidence of Alzheimer's later in life, and proposes the creation of a paired study using existing data sources that will mature within the next decade to determine individual-level relationships between childhood lead exposure and Alzheimer's incidence.
ContributorsCronin, Blake (Author) / Arquiza, Apollo (Thesis director) / Muthuswamy, Jit (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2024-05
Description
By 2050, feeding the world will require a 70% increase in food production with fewer water resources due to climate change. New strategies are needed to replace current approaches. C3 photosynthesis is inefficient due to photorespiration, but synthetic biology offers a way to increase photosynthetic efficiency and crop yields, such

By 2050, feeding the world will require a 70% increase in food production with fewer water resources due to climate change. New strategies are needed to replace current approaches. C3 photosynthesis is inefficient due to photorespiration, but synthetic biology offers a way to increase photosynthetic efficiency and crop yields, such as the tartronyl-CoA (TaCo) pathway. This project assesses the TaCo pathway in the chloroplast of Chlamydomonas reinhardtii and represents a pivotal step toward its practical application in higher plants for use in agriculture and biotechnology.
ContributorsSharma, Priyati (Author) / Cerna, Gabriella (Co-author) / Redding, Kevin (Thesis director) / Bartelle, Benjamin (Committee member) / Erb, Tobias (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2024-05
Description
This paper is a summarization of a year of projects in Dr. Xiao Wang's Synthetic Biology lab, following from initial computational projects and moving into more experimental projects under the mentorship of Dr. Kylie Standage-Beier, dealing with molecular cloning and dose response curves produced by measuring fluorescence via flow cytometry.

This paper is a summarization of a year of projects in Dr. Xiao Wang's Synthetic Biology lab, following from initial computational projects and moving into more experimental projects under the mentorship of Dr. Kylie Standage-Beier, dealing with molecular cloning and dose response curves produced by measuring fluorescence via flow cytometry. This is then integrated with a novel computational flow cytometry analysis software based on public MATLAB functions that convert flow cytometry files into MATLAB variables.
ContributorsKasen, Daniel (Author) / Wang, Xiao (Thesis director) / Standage-Beier, Kylie (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2024-05
Description
Bone loss affects millions of people every year posing a major public health problem. Currently, autograft and allograft bones are the only options for treating bone loss. Although, they pose many limitations including donor availability, immunogenicity risks, and the potential to carry a risk of disease and/or infection transmission to

Bone loss affects millions of people every year posing a major public health problem. Currently, autograft and allograft bones are the only options for treating bone loss. Although, they pose many limitations including donor availability, immunogenicity risks, and the potential to carry a risk of disease and/or infection transmission to name a few. Therefore, there is a pressing clinical need to create a novel treatment that will promote bone repair. Alpha-ketoglutarate (aKG) was investigated as it plays an important role in cellular energy metabolism as a key intermediate in the Krebs cycle. It has been shown to stimulate the production of collagen in the bone repair process. However, controlling the release of aKG is important in being able to control where and how much new bone growth is stimulated. To address this aKG was delivered via a hyaluronic acid hydrogel and its release was controlled via the degradation of poly(alpha-ketoglutarate) microparticles (paKG MPs). paKG MPs were synthesized and characterized based on size, shape, and uniformity. The release of aKG from paKG MPs was evaluated, as well as the addition of paKG MPs into norbornene functionalized hyaluronic acid and maleimide functionalized hyaluronic acid hydrogels. Initial cell work was also done to grow osteoblasts for future work. It was found that paKG MPs were of the desired size and shape. The release of aKG from the paKG MPs was found to be sustained. The addition of paKG MPs in norbornene functionalized hyaluronic acid (NorHA) was found to be ineffective due to the opaqueness of the MPs. Maleimide functionalized hyaluronic acid (MaHA) hydrogels were chosen as an alternative delivery system for this reason. Future tests will be done on the addition of paKG MPs into MaHA hydrogels. Osteoblasts were also successfully grown and will be used in future studies.
ContributorsMahadevan, Emily (Author) / Holloway, Julianne (Thesis director) / Dugoni, Margaret (Committee member) / Barrett, The Honors College (Contributor) / Economics Program in CLAS (Contributor) / Harrington Bioengineering Program (Contributor)
Created2024-05