
The transmission dynamics of Tuberculosis (TB) involve complex epidemiological and socio-economical interactions between individuals living in highly distinct regional conditions. The level of exogenous reinfection and first time infection rates within high-incidence settings may influence the impact of control programs on TB prevalence. The impact that effective population size and the distribution of individuals’ residence times in different patches have on TB transmission and control are studied using selected scenarios where risk is defined by the estimated or perceive first time infection and/or exogenous re-infection rates.
Methods
This study aims at enhancing the understanding of TB dynamics, within simplified, two patch, risk-defined environments, in the presence of short term mobility and variations in reinfection and infection rates via a mathematical model. The modeling framework captures the role of individuals’ ‘daily’ dynamics within and between places of residency, work or business via the average proportion of time spent in residence and as visitors to TB-risk environments (patches). As a result, the effective population size of Patch i (home of i-residents) at time t must account for visitors and residents of Patch i, at time t.
Results
The study identifies critical social behaviors mechanisms that can facilitate or eliminate TB infection in vulnerable populations. The results suggest that short-term mobility between heterogeneous patches contributes to significant overall increases in TB prevalence when risk is considered only in terms of direct new infection transmission, compared to the effect of exogenous reinfection. Although, the role of exogenous reinfection increases the risk that come from large movement of individuals, due to catastrophes or conflict, to TB-free areas.
Conclusions
The study highlights that allowing infected individuals to move from high to low TB prevalence areas (for example via the sharing of treatment and isolation facilities) may lead to a reduction in the total TB prevalence in the overall population. The higher the population size heterogeneity between distinct risk patches, the larger the benefit (low overall prevalence) under the same “traveling” patterns. Policies need to account for population specific factors (such as risks that are inherent with high levels of migration, local and regional mobility patterns, and first time infection rates) in order to be long lasting, effective and results in low number of drug resistant cases.

The maintenance of chromosomal integrity is an essential task of every living organism and cellular repair mechanisms exist to guard against insults to DNA. Given the importance of this process, it is expected that DNA repair proteins would be evolutionarily conserved, exhibiting very minimal sequence change over time. However, BRCA1, an essential gene involved in DNA repair, has been reported to be evolving rapidly despite the fact that many protein-altering mutations within this gene convey a significantly elevated risk for breast and ovarian cancers.
Results
To obtain a deeper understanding of the evolutionary trajectory of BRCA1, we analyzed complete BRCA1 gene sequences from 23 primate species. We show that specific amino acid sites have experienced repeated selection for amino acid replacement over primate evolution. This selection has been focused specifically on humans and our closest living relatives, chimpanzees (Pan troglodytes) and bonobos (Pan paniscus). After examining BRCA1 polymorphisms in 7 bonobo, 44 chimpanzee, and 44 rhesus macaque (Macaca mulatta) individuals, we find considerable variation within each of these species and evidence for recent selection in chimpanzee populations. Finally, we also sequenced and analyzed BRCA2 from 24 primate species and find that this gene has also evolved under positive selection.
Conclusions
While mutations leading to truncated forms of BRCA1 are clearly linked to cancer phenotypes in humans, there is also an underlying selective pressure in favor of amino acid-altering substitutions in this gene. A hypothesis where viruses are the drivers of this natural selection is discussed.
This project analyzes the experiences of South Asian asylum seekers fleeing persecution from India, Sri Lanka, and Pakistan. The latter half of this project works to analyze the reception of these asylum seekers within the United States immigration system along with potential reforms to this flawed structure.
Religion and gender are two contemporary, heavily influential social identity markers that the media engages with. In India, Bollywood simultaneously interacts with religious and gender identity by producing many movies on Hindu-Muslim inter-religious romantic relationships in the twenty-first century. Bollywood’s Hindu-Muslim romance movies are stories with a central focus on a romantic relationship in which one lover is Hindu and the second is Muslim. The masculinity and femininity of the Hindu and Muslim characters are not accidental; it is meticulously articulated in every movie. This thesis explores two sets of patterns in the movies: themes in love stories and gender identity across the protagonists. It is important to note that representation of religious identity in Bollywood is highly debated with a special emphasis on Muslim identity since they are a religious minority and the political "Other". This thesis acknowledges that the presence of Muslims in Bollywood is complicated and not black and white, but it focuses on the representation of Muslims that is connected romantically with Hindus.
This thesis aims to examine Afghan literature and feminism through the works called On Half from the East by Nadia Hashimi and Roya by Shaina and Nadia Pakrawan. For a couple of years, the Taliban has controlled Afghanistan's literature on women and feminism to silence and squash Westernized notions of freedom and rights for women. However, feminist authors continue to publish and produce many works like On Half from the East and Roya in retaliation. This thesis argues that to them, the pen is mightier than the sword, and their literature will be able to tackle the situation much better than physical retaliation, which only aggravates the situation. Through writing, women in Afghanistan can create their own identities and no longer struggle while doing so. As more and more people become aware of their situation, they hope the world will be able to provide the proper assistance they need to save them while respecting their cultures and religions carefully.