In 2014 alone, 40% of all drug abuse-related emergency department visits involved cocaine, and despite the detrimental effects there is still no FDA approved treatment for cocaine use disorders (CUDs; Dawn, 2014). Studies show that serotonin 1B receptor (5HT1BR) agonists modulate cocaine abuse-related behaviors in opposite directions depending on the phase of the addiction cycle in male rats. In particular, the selective 5HT1BR agonist, CP94,253, facilitates cocaine intake during maintenance of daily cocaine self-administration. Paradoxically, after 21 days of abstinence, CP94,253 attenuates cocaine intake in male rats on a low effort fixed ratio 5 (FR5) and a high effort progressive ratio (PR) schedule of reinforcement. PR measures motivation as it requires an exponentially increasing number of lever responses to obtain the next reinforcer after a successful reinforcer. In contrast to male rats, we recently found CP94,253 attenuates cocaine intake before and after abstinence on an FR5 schedule of reinforcement in female rats, suggesting the attenuating effects of CP94,253 on cocaine intake is not dependent on a period of abstinence in females. However, the effect of CP94,253 on motivation for cocaine has not yet been examined in female rats. Therefore, we addressed this gap in the present study. Female Sprague-Dawley rats were trained to self-administer 0.375 mg/kg, IV cocaine or to obtain sucrose pellets (45 mg) on a PR schedule of reinforcement and were then pretreated with vehicle or CP94,253 (3.2, 5.6 and 10 mg/kg, SC) prior to their self-administration session. A separate cohort was pretreated with CP94,253 to examine the effects of CP94,253 on cocaine-seeking behavior (i.e., operant responses when cocaine is no longer available) and spontaneous locomotion after 21 or 60 days of abstinence. The preliminary findings show that CP94,253 has minimal impacts on decreasing cocaine intake on a PR schedule in female rats but decreases cue reactivity up to 60 days after abstinence in female rats. These findings suggest that 5-HT1BR agonists may be useful treatments for cocaine craving.

The right to cast a meaningful vote, equal in value to other votes, is a fundamental tenet US elections. Despite the 1964 Supreme Court decision formally establishing the one person, one vote principle as a legal requirement of elections, our democracy consistently falls short of it. With mechanisms including the winner-take-all format in the Electoral College, disproportioned geographic allocation of senators, extreme partisan gerrymandering in the House of Representatives, and first-past-the-post elections, many voters experience severe vote dilution. <br/><br/>In order to legitimize our democratic structures, American elections should be reformed so every person’s vote has equal weight, ensuring that the election outcomes reflect the will of the people. Altering the current election structure to include more proportional structures including rank choice voting and population-based representation, will result in a democracy more compatible with the one person, one vote principle.

A survey was created to help gain some insight on the opinions of homeowners across the <br/>Phoenix Metro Area. This survey consisted of 7 questions relating to personal experiences and <br/>the homeowners’ opinions or concerns. The results of the survey showed that there are a few <br/>concerns surrounding solar energy with an emphasis on the cost of maintenance of panels and <br/>the payback period where the homeowners would see a return on their investment. Most of the <br/>homeowners answered that they do not use solar energy but have thought about using it for their <br/>main source of energy before. The homeowners in the survey also thought that solar energy was <br/>overall too expensive and that it would take a long time before they would see any payoff or <br/>savings from the solar panels. It was found that the payback period for panels is around 7 years <br/>and that depending on the size of the solar system installed or on the model used, solar panels <br/>cost much less than many people think. This was found by researching non-biased resources <br/>from government websites and from local energy companies’ websites. To combat the concerns <br/>found from the survey, an infographic was created to help inform the public about solar energy <br/>and allow the homeowners to make decisions that are well informed and not based on <br/>misinformation. The infographic included information related to the survey by explaining the <br/>survey and explaining topics that were of concern to the homeowners who took the survey. In <br/>addition, the infographic displayed information about solar energy and that the decision to use <br/>solar is ultimately up to the audience.

Descriptive representation is important to building and maintaining a fair court system, especially within a context of historical oppression by race or gender. Using official government biographies, voter rolls, news articles, and press releases, I collected demographic information on the judges of Arizona and compared it to Census data, to show how under representative the state courts of Arizona currently are. Through the use of non-attorney judges, the Justice Court of Arizona has become the most representative level of the state court. Almost all of the BIPOC judges of the Justice Court are not attorneys. Allowing non-attorney Justices of the Peace has made it possible for the court to be more representative of Arizonans. However, even though it is the most representative state court, the Justice Court vastly under represents women and BIPOC as judges. As racial tension and movements for fairness under the law increase, it is important to challenge how the courts could better serve Arizona.