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Description
Lipid microdomains play a vital role in a number of biological processes. They are often a target of diseases and viruses. Viruses in particular utilize lipid microdomains to gain entry and fuse with the host-cell membrane. Measles virus (MV) a human pathogen, spread from cell to cell by inducing fusion of cellular membranes. This causes the formation of large multinucleated cells, syncytia. It has been previously reported that lipid microdomains are essential for measles virus infection/replication. In this study we used methyl beta cyclodextrin (MBCD), a cholesterol-sequestering agent to disrupt lipid microdomains. Through transfection of Vero h/SLAM cells, we found that Measles virus fusion was dependent on lipid microdomains integrity. Indeed, a dose dependent fusion inhibition was documented with increasing concentrations of MBCD resulting in reduced formation of syncytia.
ContributorsKwan, Jason (Author) / Reyes del Valle, Jorge (Thesis director) / Chang, Yung (Committee member) / Mor, Tsafrir (Committee member) / Barrett, The Honors College (Contributor) / Department of Finance (Contributor) / School of Life Sciences (Contributor)
Created2013-05
Description
This was a social movements analysis of the protests against Arizona's Senate Bill 1070, better known as the "Show Me your Papers" law. The project looked at the role religious organizations and religious leaders took in the protests as part of the immigration rights movement in Arizona. It was found that there were frames, networks, and resources already in place when SB 1070 passed in 2010. Rather than a movement emerging as a response to the legislation, it looked more like a social movement in crisis. The established frames, networks, and resources allowed this social movement to meet the challenge and have some measure of success in resisting and overturning SB 1070.
ContributorsMcInnis, Haley Marhon (Author) / Ingram-Waters, Mary (Thesis director) / Menjivar, Cecilia (Committee member) / Bruhn, Karen (Committee member) / Barrett, The Honors College (Contributor) / T. Denny Sanford School of Social and Family Dynamics (Contributor) / Department of Psychology (Contributor)
Created2013-05
DescriptionDiagnosis is an analysis of human behavior, examined through several types of poetry. The project delves into how individuals act and re-act when put into stress-inducing situations, whether due to that situation, personality, traits, an interaction with another person, or mental illness.
ContributorsBreisblatt, Faith Wood (Author) / Hogue, Cynthia (Thesis director) / Humphrey, Ted (Committee member) / Goldberg, Beckian Fritz (Committee member) / Barrett, The Honors College (Contributor) / T. Denny Sanford School of Social and Family Dynamics (Contributor) / Department of Psychology (Contributor) / Department of English (Contributor)
Created2013-05
Description
The Community Action Research Experiences (CARE) Program collaborated with the WellCare Foundation (WCF) to assess the referral sources of the clinic in order to more effectively reach additional potential patients. Archival data were analyzed from a 19-month period from the medical records of patients. Also, data were collected from interviews with the case manager of agencies that were a known referral source of WCF. These case manager interviews were completed over a one-month period. For the archival data part of the project, data were collected from 117 patients. Four representatives from community agencies participated in phone interviews. The results indicated that the most common referral sources were word of mouth, followed by community agency referrals. The results also indicated that WCF appears to have served a unique niche that is not served by other non-profit health clinics. These results led to implications for action and direction for future applied research.
ContributorsEbbing, Brittany Gabrielle (Author) / Spinrad, Tracy (Thesis director) / Dumka, Larry (Committee member) / Brougham, Jennifer (Committee member) / Barrett, The Honors College (Contributor) / T. Denny Sanford School of Social and Family Dynamics (Contributor) / School of Life Sciences (Contributor)
Created2013-05
Description
Misfolding and aggregation of alpha-synuclein (a-syn) has been strongly correlated with the pathogenesis of Parkinson's disease (PD). Reagents such as single chain antibody fragments (scFv) that can interact with specific aggregate forms of a-syn can be very useful to study how different aggregate forms affect cells. Here we utilize two scFvs, D5 and 10H, that recognize two distinct oligomeric forms of a-syn to characterize the presence of different a-syn aggregates in animal models of PD.
ContributorsAlam, Now Bahar (Author) / Sierks, Michael (Thesis director) / Pauken, Christine (Committee member) / Williams, Stephanie (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / Harrington Bioengineering Program (Contributor)
Created2013-05
Description
Abstract As we move forward in education reform in the globalized 21st century, the United States must visit new ways to teach science in high school classrooms. The goal of this investigation is to analyze the current research literature for the best and most promising teaching strategies and techniques in secondary education biology classrooms that promote academic excellence for all students. Looking at policy and school reform literature in science education to establish the context of the current system, the paper will not focus on the political as or systematic changes needed to ground an overall successful system. However, because of their inherent effect on the education system, the political aspects of education reform will be briefly addressed. The primary focus, by addressing the emphasis on standardization, inflexibility of instruction and lack of creativity specifically in high school biology classrooms, seeks to clarify small changes that can influence students' academic outcomes. The United States is performing on such a poor level in science and math proficiency that it cannot match students abroad and this is seen through test scores and the production of competent graduates. This investigation serves to organize literature from education researchers and showcase best and promising teaching and learning practices that catalyze academic excellence for all students in our pluralistic, democratic and complex schooling and societal contexts.
ContributorsHildebrandt, Kevin Andrew (Author) / Ovando, Carlos (Thesis director) / Schugurensky, Daniel, 1958- (Committee member) / Fischman, Gustavo (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / School of International Letters and Cultures (Contributor)
Created2013-05
Description
Previous findings from our lab have demonstrated that nicotine and social reward have synergistic effects when experienced together versus when experienced separately. The purpose of this experiment is to understand the neural mechanisms underlying this synergistic effect by quantifying Fos protein, a marker for neural activation, in various brain regions. We utilized the conditioning place preference (CPP) model to assess reward. Four groups of adolescent male rats (n=120) were given either nicotine (Nic) (0.1 mg/kg/mL) or saline (Sal) and were placed in the CPP apparatus either with a social partner (Soc) or alone (Iso). Thus, groups were: 1.)Sal+Iso, 2).Sal+Soc, 3).Nic+Iso, 4).Nic+Soc. Brains of some the rats (n=40) were collected for Fos staining 90 minutes after the last conditioning session to obtain Fos data in response to direct exposure to the stimuli. The following regions were analyzed for Fos expression: central amygdala (CeA), medial amygdala (MeA), basolateral amygdala (BLA), nucleus accumbens core (NAcCore), and nucleus accumbens shell (NAcShell). Place preference changes occurred in socially-conditioned groups reflecting social reward and in nicotine-conditioned groups reflecting nicotine reward. As expected, the Sal+Iso control group failed to display a preference change. Fos data revealed a significant increase in Fos expression in the CeA, MeA, NAcCore and NAcShell for socially-conditioned animals and a significant decrease in the NAcCore for nicotine-conditioned groups. Experiencing both social and nicotine rewards together appeared to produce greater activation in the BLA. However, there was an increase in Fos expression in the negative control group relative to Nic+Iso group. The results of CPP suggest that social, nicotine and their combination are rewarding. The combination of the nicotine and social reward could have been more rewarding than social and nicotine separately, but the test was not sensitive to reward magnitude. The increase in Fos expression in the negative control group in the BLA could be due to isolation stress. Overall, these results suggest that these brain regions had greater activation to social reward.
ContributorsGoenaga, Julianna Gloria (Author) / Neisewander, Janet (Thesis director) / Orchinik, Miles (Committee member) / Olive, Michael (Committee member) / Barrett, The Honors College (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor) / School of Life Sciences (Contributor)
Created2013-05
Description
Many of the derived features of the human skeleton can be divided into two adaptive suites: traits related to bipedalism and traits related to encephalization. The cervical spine connects these adaptive suites and is itself unique in its marked lordosis. I approach human cervical evolution from three directions: the functional significance of cervical curvature, the identification of cervical lordosis in osteological material, and the representation of the cervical spine in the hominin fossil record.
ContributorsFatica, Lawrence Martin (Author) / Kimbel, William (Thesis director) / Reed, Kaye (Committee member) / Schwartz, Gary (Committee member) / Barrett, The Honors College (Contributor) / School of Human Evolution and Social Change (Contributor) / School of Life Sciences (Contributor)
Created2014-05
Description
This paper takes a look at developing a technological start up revolving around the world of health and fitness. The entire process is documented, starting from the ideation phase, and continuing on to product testing and market research. The research done focuses on identifying a target market for a 24/7 fitness service that connects clients with personal trainers. It is a good study on the steps needed in creating a business, and serves as a learning tool for how to bring a product to market.
ContributorsHeck, Kyle (Co-author) / Mitchell, Jake (Co-author) / Korczynski, Brian (Co-author) / Peck, Sidnee (Thesis director) / Eaton, John (Committee member) / Barrett, The Honors College (Contributor) / Department of Finance (Contributor) / Department of Economics (Contributor) / Department of Management (Contributor) / Department of Psychology (Contributor) / Department of Supply Chain Management (Contributor) / School of Accountancy (Contributor) / W. P. Carey School of Business (Contributor)
Created2014-05
Description
It is well known that deficiencies in key chemical elements (such as phosphorus, P) can reduce animal growth; however, recent empirical data have shown that high levels of dietary nutrients can also reduce animal growth. In ecological stoichiometry, this phenomenon is known as the "stoichiometric knife edge," but its underlying mechanisms are not well-known. Previous work has suggested that the crustacean zooplankter Daphnia reduces its feeding rates on phosphorus-rich food, causing low growth due to insufficient C (energy) intake. To test for this mechanism, feeding rates of Daphnia magna on algae (Scenedesmus acutus) differing in C:P ratio (P content) were determined. Overall, there was a significant difference among all treatments for feeding rate (p < 0.05) with generally higher feeding rates on P-rich algae. These data indicate that both high and low food C:P ratio do affect Daphnia feeding rate but are in contradiction with previous work that showed that P-rich food led to strong reductions in feeding rate. Additional experiments are needed to gain further insights.
ContributorsSchimpp, Sarah Ann (Author) / Elser, James (Thesis director) / Neuer, Susanne (Committee member) / Peace, Angela (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / School of Sustainability (Contributor)
Created2014-05