Matching Items (908)
Description
Lipid microdomains play a vital role in a number of biological processes. They are often a target of diseases and viruses. Viruses in particular utilize lipid microdomains to gain entry and fuse with the host-cell membrane. Measles virus (MV) a human pathogen, spread from cell to cell by inducing fusion

Lipid microdomains play a vital role in a number of biological processes. They are often a target of diseases and viruses. Viruses in particular utilize lipid microdomains to gain entry and fuse with the host-cell membrane. Measles virus (MV) a human pathogen, spread from cell to cell by inducing fusion of cellular membranes. This causes the formation of large multinucleated cells, syncytia. It has been previously reported that lipid microdomains are essential for measles virus infection/replication. In this study we used methyl beta cyclodextrin (MBCD), a cholesterol-sequestering agent to disrupt lipid microdomains. Through transfection of Vero h/SLAM cells, we found that Measles virus fusion was dependent on lipid microdomains integrity. Indeed, a dose dependent fusion inhibition was documented with increasing concentrations of MBCD resulting in reduced formation of syncytia.
ContributorsKwan, Jason (Author) / Reyes del Valle, Jorge (Thesis director) / Chang, Yung (Committee member) / Mor, Tsafrir (Committee member) / Barrett, The Honors College (Contributor) / Department of Finance (Contributor) / School of Life Sciences (Contributor)
Created2013-05
Description
This paper takes a look at developing a technological start up revolving around the world of health and fitness. The entire process is documented, starting from the ideation phase, and continuing on to product testing and market research. The research done focuses on identifying a target market for a 24/7

This paper takes a look at developing a technological start up revolving around the world of health and fitness. The entire process is documented, starting from the ideation phase, and continuing on to product testing and market research. The research done focuses on identifying a target market for a 24/7 fitness service that connects clients with personal trainers. It is a good study on the steps needed in creating a business, and serves as a learning tool for how to bring a product to market.
ContributorsHeck, Kyle (Co-author) / Mitchell, Jake (Co-author) / Korczynski, Brian (Co-author) / Peck, Sidnee (Thesis director) / Eaton, John (Committee member) / Barrett, The Honors College (Contributor) / Department of Finance (Contributor) / Department of Economics (Contributor) / Department of Management (Contributor) / Department of Psychology (Contributor) / Department of Supply Chain Management (Contributor) / School of Accountancy (Contributor) / W. P. Carey School of Business (Contributor)
Created2014-05
Description
This project is an investigation into the many financial issues professional athletes face. These issues include bad spending habits, poor investments, freeloaders (posses/entourages), and more. Following is an explanation of Financial Planning and Wealth Management, and how the application of these strategies and tactics - specifically the use of Sustainable

This project is an investigation into the many financial issues professional athletes face. These issues include bad spending habits, poor investments, freeloaders (posses/entourages), and more. Following is an explanation of Financial Planning and Wealth Management, and how the application of these strategies and tactics - specifically the use of Sustainable Withdrawal Rates in a Capital Sufficiency Analysis - can help to avoid such issues. An illustration of these practices "in action" is given through a case study of fictional athletes and portfolios. Lastly, recommendations are given on potential solutions that could help prevent these problems from affecting more athletes.
ContributorsCastellani, Robert Thomas (Author) / Eaton, John (Thesis director) / Cassidy, Nancy (Committee member) / Judge, Evan (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / WPC Graduate Programs (Contributor) / W. P. Carey School of Business (Contributor) / School of Accountancy (Contributor)
Created2014-05
Description
For many years, the countries of Sub-Saharan Africa, like many other unindustrialized nations, followed the internally-oriented import substitution policies developed by theoreticians like Raul Prebisch. These measures were meant to force nations to develop their industrial capabilities in isolation from the rest of the world. However, these policies did little

For many years, the countries of Sub-Saharan Africa, like many other unindustrialized nations, followed the internally-oriented import substitution policies developed by theoreticians like Raul Prebisch. These measures were meant to force nations to develop their industrial capabilities in isolation from the rest of the world. However, these policies did little to improve the economy of many emerging countries. It was not until Asian countries switched to externally-oriented strategies that progress was made in their developing economies. In the early 1980s, a "Washington Consensus" was practiced that included a trade provision for the opening of emerging markets. Since then, many Sub-Saharan African nations have implemented policies that have opened up their markets to the rest of the world. However, most of these countries have not realized the benefits typically ascribed to open trade, causing some economists to doubt the economic growth benefits of trade liberalization. This thesis examines the connection between trade liberalization in Sub-Saharan Africa to review the consequences of recent trade reforms on the region's development and to identify some of the factors which contributed to individual countries successfully, or unsuccessfully, implementing trade liberalizing policies. It finds that the relationship between economic growth and trade liberalization is not as important as other growth factors and that there are multiple paths toward economic development.
ContributorsDussik, Jonathan Abraham DeBlock (Author) / DeSerpa, Allan (Thesis director) / Hill, John (Committee member) / Barrett, The Honors College (Contributor) / Department of Finance (Contributor) / Department of Economics (Contributor)
Created2014-12
Description
Peoria, a city of about 171,000 residents in the northwest Valley, is recognized as one of Arizona's fastest growing cities. Peoria does not have a news source that engages millennials, despite the fact that adults ages 18 to 34 make up about 20% of Peoria's population. Thus, I created a

Peoria, a city of about 171,000 residents in the northwest Valley, is recognized as one of Arizona's fastest growing cities. Peoria does not have a news source that engages millennials, despite the fact that adults ages 18 to 34 make up about 20% of Peoria's population. Thus, I created a digital news outlet with a complementary social media presence to target a millennial audience. Peoria Next covers news about Peoria that is either not currently covered by other news outlets or is covered in a different way. The goal of the website is to inform millennials of news and events in Peoria with a focus on topics millennials are interested in. The website receives 40 to 50 unique visitors and around 90 views every month, and Facebook insights show that 32% of the people reached by Peoria Next are in the target age range of 18 to 34. This paper discusses the process involved in creating a news outlet for millennials in Peoria with social media platforms as the main avenue for audience development. The first section discusses the role of local news in a community, using social media to engage the audience and how millennials receive and engage with news. The second section discusses how I developed the website and the overall results.
ContributorsRogers, Anya Bryn (Author) / Leonard, Christina (Thesis director) / Pucci, Jessica (Committee member) / WPC Graduate Programs (Contributor) / Economics Program in CLAS (Contributor) / Walter Cronkite School of Journalism and Mass Communication (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description

In today's business environment, customer service is more critical than ever. It is a major factor when consumers decide where to take their business. However, consumer choice is not applicable to all businesses for example, public utilities. Consumers do not have a choice in picking which utility company provides them

In today's business environment, customer service is more critical than ever. It is a major factor when consumers decide where to take their business. However, consumer choice is not applicable to all businesses for example, public utilities. Consumers do not have a choice in picking which utility company provides them service; the choice depends upon local jurisdictions and predetermined service territories. This lack of choice creates a "forced relationship" between consumers and public utilities. Because the nature of this relationship can have a negative impact, public utilities need to reevaluate their approach and invest in effective customer service as a valuable tool to achieve their organizational goals. This study investigates the need for public utilities to expand their investment; explores the available avenues to expand their investment; and offers a recommended pathway with the features and interface to expand their investment. Technology is the key in achieving organizational goals as it can reengineer internal and external operations. Self-service technology (SST) along with the features of gamification enable an organization to reengineer both its internal and its external operations. Companies can shift work from employees to customers and develop new mediums for customer service interaction. Overall, three investments are analyzed: traditional call centers, online, and mobile. The analysis focuses on available features and how those features affect the achievement of organizational goals. Two studies comprise interviews with utility representatives and a customer survey completed to reinforce findings. Based on the research, a smartphone application is the best option to enhance customer service while addressing all organizational goals.

ContributorsKosednar, Andrew Steven (Author) / Eaton, Kathryn (Thesis director) / Brendza, Daniel (Committee member) / WPC Graduate Programs (Contributor) / School of Accountancy (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description

This thesis examines the value creation potential of renovating an existing commercial real estate asset to a medical office. It begins by examining commercial real estate and the medical sector at a high level. It then discusses the various criteria used to select a subject property for renovation. This renovation

This thesis examines the value creation potential of renovating an existing commercial real estate asset to a medical office. It begins by examining commercial real estate and the medical sector at a high level. It then discusses the various criteria used to select a subject property for renovation. This renovation is then depicted through a modified pitch book that contains a financial model and pro forma.

ContributorsPeters, Matthew Scott (Co-author) / Larrea, Justin (Co-author) / Berger, Nicholas (Co-author) / Simonson, Mark (Thesis director) / Gray, William (Committee member) / Department of Finance (Contributor, Contributor) / Department of Information Systems (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

A podcast that discusses the phenomenon of cult cinema deemed “so bad, it's good”. It takes a look at what makes these films enduring and entertaining, with the ability to create near-religious followings. Moreover, it discusses the financial aspect of the filmmaking and how these followings affect the market.

ContributorsFischler, Max Caskey (Co-author) / Stone, Zac (Co-author) / Schmidt, Peter (Thesis director) / Mack, Robert (Committee member) / School of Accountancy (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

Supply chain management is becoming an increasingly vital component in the success of an organization. Business and government leaders continue to recognize the importance of having robust and resilient supply chains. This trend has been accelerated by the COVID-19 pandemic which brought to light the fragility of the modern global

Supply chain management is becoming an increasingly vital component in the success of an organization. Business and government leaders continue to recognize the importance of having robust and resilient supply chains. This trend has been accelerated by the COVID-19 pandemic which brought to light the fragility of the modern global supply chain network. Decades of offshoring has led to the inability of businesses to adequately manufacture critical supplies in times of crisis. This reality is most prevalent in the healthcare industry. Antibiotics, pharmaceuticals, PPE, testing equipment are almost entirely sourced from Chinese manufacturers. Building a more resilient healthcare supply chain requires a revaluation of critical items, cooperation between businesses and government, and recognizing the precarious situation for the United States which has become completely reliant on foreign manufacturers. <br/> Businesses are looking to develop more resilient supply chains which can respond and predict unforeseen market circumstances. The federal government is reckoning the national security concern of sourcing nearly all antibiotics, and pharmaceuticals from Chinese manufacturers. Aligning the goals of key stakeholders and developing the necessary incentive structure to encourage domestic manufacturing is necessary to respond to this crisis. As the global economy becomes increasingly interconnected and dependent on changes to markets anywhere on the globe, a renewed focus on proactive strategies is necessary to ensure the security and resiliency of the United States healthcare supply chain.

ContributorsKeelan, Kristopher (Author) / Printezis, Antonios (Thesis director) / Blackmer, Cindie (Committee member) / Department of Finance (Contributor) / Department of Supply Chain Management (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

In the current race for technological innovation, companies are striving to be the best and most prominent in the industry. A major way companies are setting themselves apart is through personalized experiences for their customers, so they have a huge incentive to collect consumer information. Consumers have limited knowledge of

In the current race for technological innovation, companies are striving to be the best and most prominent in the industry. A major way companies are setting themselves apart is through personalized experiences for their customers, so they have a huge incentive to collect consumer information. Consumers have limited knowledge of how much information companies collect and what goes on behind the scenes. Therefore, it is becoming extremely important to ensure companies are held accountable for upholding consumers’ right to privacy. One way this can be done is through the implementation of privacy legislation. The United States has not yet enacted federal preemptive privacy legislation, so this thesis examines the feasibility of enacting such legislation using the European Union’s GDPR as a model. California’s current state-level privacy law, the CCPA, is compared to the GDPR to determine the elements of a successful privacy law and find that the CCPA has many problems, most of which are solved by the GDPR. Because of this, it is concluded that it is necessary for the United States to adopt federal privacy legislation which would be most successful if the GDPR was used as a foundation.

ContributorsVance, Kaitlyn Michelle (Author) / Voorhees, Matthew (Thesis director) / Barnard, Catherine (Committee member) / Dean, W.P. Carey School of Business (Contributor) / Department of Finance (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05