Matching Items (1,065)
Description
Background: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer deaths in females worldwide, accounting for 23% of all new cancer cases and 14% of all total cancer deaths in 2008. Five tumor-normal pairs of primary breast epithelial cells were treated for infinite proliferation by

Background: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer deaths in females worldwide, accounting for 23% of all new cancer cases and 14% of all total cancer deaths in 2008. Five tumor-normal pairs of primary breast epithelial cells were treated for infinite proliferation by using a ROCK inhibitor and mouse feeder cells. Methods: Raw paired-end, 100x coverage RNA-Seq data was aligned to the Human Reference Genome Version 19 using BWA and Tophat. Gene differential expression analysis was completed using Cufflinks and Cuffdiff. Interactive Genome Viewer was used for data visualization. Results: 15 genes were found to be down-regulated by at least one log-fold change in 4/5 of tumor samples. 75 genes were found to be down-regulated in 3/5 of our tumor samples by at least one log-fold change. 11 genes were found to be up-regulated in 4/5 of our tumor samples, and 68 genes were identified to be up-regulated in 3/5 of the tumor samples by at least one-fold change. Conclusion: Expression changes in genes such as AZGP1, AGER, ALG11, and S1007 suggest a disruption in the glycosylation pathway. No correlation was found between Cufflink's Her2 gene-expression and DAKO score classification.
ContributorsHernandez, Fernando (Author) / Anderson, Karen (Thesis director) / Mangone, Marco (Committee member) / Park, Jin (Committee member) / Barrett, The Honors College (Contributor) / Department of Information Systems (Contributor)
Created2013-05
Description
The US steel industry experienced a great decline between 1950-1985. Influenced by several government policies, the industry was first cartelized during the great depression and then subjected to an extremely powerful organized labor force. Due to high demand between and during WWII and the Korean War, the industry expanded capacity

The US steel industry experienced a great decline between 1950-1985. Influenced by several government policies, the industry was first cartelized during the great depression and then subjected to an extremely powerful organized labor force. Due to high demand between and during WWII and the Korean War, the industry expanded capacity using existing technologies. Simultaneously, organized labor was able to secure increased wages and large severance costs for firms that decided to shutdown existing steel mills. In the post war years this prevented firms from innovating through investing in newer, more efficient, technologies. Eventually US steel firms had no advantage against foreign producers who could produce steel cheaper and more efficiently.
ContributorsCole, Andrew Arthur (Author) / Lagakos, David (Thesis director) / DeSerpa, Allan (Committee member) / Dillon, Eleanor (Committee member) / Barrett, The Honors College (Contributor) / Economics Program in CLAS (Contributor)
Created2013-05
Description
This paper takes a look at developing a technological start up revolving around the world of health and fitness. The entire process is documented, starting from the ideation phase, and continuing on to product testing and market research. The research done focuses on identifying a target market for a 24/7

This paper takes a look at developing a technological start up revolving around the world of health and fitness. The entire process is documented, starting from the ideation phase, and continuing on to product testing and market research. The research done focuses on identifying a target market for a 24/7 fitness service that connects clients with personal trainers. It is a good study on the steps needed in creating a business, and serves as a learning tool for how to bring a product to market.
ContributorsHeck, Kyle (Co-author) / Mitchell, Jake (Co-author) / Korczynski, Brian (Co-author) / Peck, Sidnee (Thesis director) / Eaton, John (Committee member) / Barrett, The Honors College (Contributor) / Department of Finance (Contributor) / Department of Economics (Contributor) / Department of Management (Contributor) / Department of Psychology (Contributor) / Department of Supply Chain Management (Contributor) / School of Accountancy (Contributor) / W. P. Carey School of Business (Contributor)
Created2014-05
Description
This project is an investigation into the many financial issues professional athletes face. These issues include bad spending habits, poor investments, freeloaders (posses/entourages), and more. Following is an explanation of Financial Planning and Wealth Management, and how the application of these strategies and tactics - specifically the use of Sustainable

This project is an investigation into the many financial issues professional athletes face. These issues include bad spending habits, poor investments, freeloaders (posses/entourages), and more. Following is an explanation of Financial Planning and Wealth Management, and how the application of these strategies and tactics - specifically the use of Sustainable Withdrawal Rates in a Capital Sufficiency Analysis - can help to avoid such issues. An illustration of these practices "in action" is given through a case study of fictional athletes and portfolios. Lastly, recommendations are given on potential solutions that could help prevent these problems from affecting more athletes.
ContributorsCastellani, Robert Thomas (Author) / Eaton, John (Thesis director) / Cassidy, Nancy (Committee member) / Judge, Evan (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / WPC Graduate Programs (Contributor) / W. P. Carey School of Business (Contributor) / School of Accountancy (Contributor)
Created2014-05
Description
This report analyzes the intersection that is present between law and technology. It covers the basics of patents and intellectual property law, and then touches briefly about the software side of patent law. The future of patent and technology law are explored as well. The main focus of this report

This report analyzes the intersection that is present between law and technology. It covers the basics of patents and intellectual property law, and then touches briefly about the software side of patent law. The future of patent and technology law are explored as well. The main focus of this report is the patent that was created for a beacon that provides for a full enterprise resource planning solution at both supply chain and full business levels.
ContributorsShah, Dhara Vimesh (Author) / Michelle, Gross (Thesis director) / Stevens, Yvonne (Committee member) / Department of Information Systems (Contributor) / W. P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Peoria, a city of about 171,000 residents in the northwest Valley, is recognized as one of Arizona's fastest growing cities. Peoria does not have a news source that engages millennials, despite the fact that adults ages 18 to 34 make up about 20% of Peoria's population. Thus, I created a

Peoria, a city of about 171,000 residents in the northwest Valley, is recognized as one of Arizona's fastest growing cities. Peoria does not have a news source that engages millennials, despite the fact that adults ages 18 to 34 make up about 20% of Peoria's population. Thus, I created a digital news outlet with a complementary social media presence to target a millennial audience. Peoria Next covers news about Peoria that is either not currently covered by other news outlets or is covered in a different way. The goal of the website is to inform millennials of news and events in Peoria with a focus on topics millennials are interested in. The website receives 40 to 50 unique visitors and around 90 views every month, and Facebook insights show that 32% of the people reached by Peoria Next are in the target age range of 18 to 34. This paper discusses the process involved in creating a news outlet for millennials in Peoria with social media platforms as the main avenue for audience development. The first section discusses the role of local news in a community, using social media to engage the audience and how millennials receive and engage with news. The second section discusses how I developed the website and the overall results.
ContributorsRogers, Anya Bryn (Author) / Leonard, Christina (Thesis director) / Pucci, Jessica (Committee member) / WPC Graduate Programs (Contributor) / Economics Program in CLAS (Contributor) / Walter Cronkite School of Journalism and Mass Communication (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Over the course of 2015-2017, the ASU-SCMA/UASGC Outreach program was developed at Arizona State University (ASU) to support both high school students and college students interested in supply chain management careers. In particular, the program targets the high school students of the Urban Assembly School for Global Commerce (UASGC) and

Over the course of 2015-2017, the ASU-SCMA/UASGC Outreach program was developed at Arizona State University (ASU) to support both high school students and college students interested in supply chain management careers. In particular, the program targets the high school students of the Urban Assembly School for Global Commerce (UASGC) and the college students of the ASU Supply Chain Management Association (ASU-SCMA). High school students are partnered with college students in a year-long mentoring program that allows both parties to develop professional supply chain skills. The work of the ASU-SCMA/UASGC Outreach Program is particularly important because it provides UASGC with much needed resources to address urban poverty issues in New York using career and technical education. The Urban Assembly describes its student group as "at-risk, under-resourced youth," and of those youth: - 85% are low-income - 83% enter high school below grade level in at least one subject - 20% require Individualized Education Plans (Special Needs) (urbanassembly.org). The Outreach Program addresses the above issues by providing the high school students with collegiate mentors that develop supply chain and college readiness resources in the form of a case study, site tour, supply chain simulation and presentations. In order to be considered successful, the program must first, equip the high school mentees with tools and skills for a professional career, specifically supply chain management, that they would not otherwise be exposed to; and second, motivate the collegiate participants who are about to enter the workforce to continue to participate in mentoring throughout their careers. This program documents the efforts and results of the pilot year for the Outreach Program that took place from September 2016 through March 2017. Through this pilot program, it was determined that the ASU-SCMA/UASGC Outreach Program is effective and valuable. In fact, the program found that: - 75% of the high school students agreed or strongly agreed that the program helped them learn new business skills. - 75% of the high school students agreed that the program taught them new, interesting things about supply chain. - 75% of the high school students became more interested in college. 100% of the college mentors agreed or strongly agreed that they gained new and important supply chain and professional skills. The success of the pilot year has led to plans for the Outreach Program to become an annual project for ASU-SCMA. This is a program that will continue for the foreseeable future.
ContributorsLam, Tiffany Ai (Author) / Davila, Eduardo (Thesis director) / Manfredo, Mark (Committee member) / Department of Economics (Contributor) / Department of Information Systems (Contributor) / Department of Supply Chain Management (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
This ethnography outlines the live storytelling culture in Phoenix, Arizona, and what each of its sub-cultures contributes to the city's community. Phoenix's live storytelling events incorporate elements of an ancient art form into contemporary entertainment and sophisticated platforms for community building. These events are described and delineated by stylistic, structural,

This ethnography outlines the live storytelling culture in Phoenix, Arizona, and what each of its sub-cultures contributes to the city's community. Phoenix's live storytelling events incorporate elements of an ancient art form into contemporary entertainment and sophisticated platforms for community building. These events are described and delineated by stylistic, structural, and content-based differences into the following categories: open-mic, curated, scripted, non-scripted, micro-culture, and marginalized groups. Research presented in this report was collected by reviewing scholarly materials about the social power of storytelling, attending live storytelling events across all categories, and interviewing event organizers and storytellers. My research developed toward an auto-ethnographic direction when I joined the community of storytellers in Phoenix, shifting the thesis to assume a voice of solidarity with the community. This resulted in a research project framed primarily as an ethnography that also includes my initial, personal experiences as a storyteller. The thesis concludes with the art form's macro-influences on Phoenix's rapidly-expanding community.
ContributorsNorton, Maeve (Author) / Dombrowski, Rosemarie (Thesis director) / McAdams, Charity (Committee member) / School of International Letters and Cultures (Contributor) / Department of Information Systems (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12
Description
I use Arizona State University's rebranding initiative with Nike as a starting point for examining how partnerships between elite brands and universities affect different types of students. I draw from literature on self-completion theory and identity salience to suggest that there are differences between athletes and non-athletes in how they

I use Arizona State University's rebranding initiative with Nike as a starting point for examining how partnerships between elite brands and universities affect different types of students. I draw from literature on self-completion theory and identity salience to suggest that there are differences between athletes and non-athletes in how they believe elite sportswear products may affect their athletic performance. I propose that athletes feel more "complete" than non-athletes because they are more proficient in their respective sport. As such, non-athletes are more likely to use sportswear products (Nike) to become more proficient in athletics and have stronger beliefs that elite sportswear products will help them arrive at their goals. I also propose and find that students who feel that ASU plays an important part of their life perceive even greater performance boosts from using Nike products. These findings suggest that particular attention should be paid to the athletes and non-athletes in initiatives that link specific institutions and organizations to performance brands.
ContributorsGoldman, Alexa (Author) / Eaton, John (Thesis director) / Samper, Adriana (Committee member) / Kohler, Michael (Committee member) / Barrett, The Honors College (Contributor) / W. P. Carey School of Business (Contributor)
Created2012-12
Description

This thesis examines the value creation potential of renovating an existing commercial real estate asset to a medical office. It begins by examining commercial real estate and the medical sector at a high level. It then discusses the various criteria used to select a subject property for renovation. This renovation

This thesis examines the value creation potential of renovating an existing commercial real estate asset to a medical office. It begins by examining commercial real estate and the medical sector at a high level. It then discusses the various criteria used to select a subject property for renovation. This renovation is then depicted through a modified pitch book that contains a financial model and pro forma.

ContributorsPeters, Matthew Scott (Co-author) / Larrea, Justin (Co-author) / Berger, Nicholas (Co-author) / Simonson, Mark (Thesis director) / Gray, William (Committee member) / Department of Finance (Contributor, Contributor) / Department of Information Systems (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05