Alginate microspheres have recently become increasingly popular in the realm of drug delivery for their biocompatibility, nontoxicity, inexpensiveness, among other factors. Recent strict regulations on microsphere size have drastically increased manufacturing cost and waste, even though the effect of size variance on drug delivery and subsequent performance is unclear. If sphere size variance does not significantly affect drug release profiles, it is possible that future ordinances may loosen tolerances in manufacturing to limit waste produced and expenditures. We use a mathematical model developed by Nickel et al. [12], to theoretically predict drug delivery profiles based on sphere size, and correlate the expected release with experimental data. This model considers diffusion as the key component for drug delivery, which is defined by Fick’s Laws of Diffusion. Alginate, chosen for its simple fabrication method and biocompatibility, was formed into microspheres with a modified extrusion technique and characterized by size. Size variance was introduced in batches and delivery patterns were compared to control groups of identical size. Release patterns for brilliant blue dye, the mock drug chosen, were examined for both groups via UV spectrometry. The absorbance values were then converted to concentration value using a calibration curve done prior to experimentation. The concentration values were then converted to mass values. These values then produced curves representing the mass of the drug released over time. Although the control and experimental values were statistically significantly different, the curves were rather similar to each other. However, when compared to the predicted release pattern, the curves were not the same. Unexpected degradation caused this dissimilarity between the curves. The predictive model was then adjusted to account for degradation by changing the diffusion coefficient in the code to a reciprocal first order exponent. The similarity between the control and experimental curves can insinuate the notion that size tolerances for microsphere production can be somewhat lenient, as a batch containing fifteen beads of the same size and one with three different sizes yields similar release patterns.

Toy hacks modify commercially available toys to be more easily used by people with motor disabilities, and donate them to schools, families, or toy libraries. Switch-adapting a toy adds an audio jack to allow an assistive technology (AT) switch to be plugged in. Switch-adapted toys help children develop essential skills through play. Hacking toys is helpful because toys that come with AT switches are often significantly more expensive than their unadapted counterparts. Toy hacks are also an opportunity to teach and practice engineering skills such as soldering and technical problem solving. Many resources are available online to assist makers with hosting toy hacks, but most of them lack information on holding the event. To fill this gap, the authors created a toy hack guide website, drawing from experience hosting two toy hacks. It walks users through steps like choosing the size of the event, the materials that need to be purchased, and connects them to other existing resources. In the future, it will be used to help people host more successful toy hacks.

Toy hacks modify commercially available toys to be more easily used by people with motor disabilities, and donate them to schools, families, or toy libraries. Switch-adapting a toy adds an audio jack to allow an assistive technology (AT) switch to be plugged in. Switch-adapted toys help children develop essential skills through play. Hacking toys is helpful because toys that come with AT switches are often significantly more expensive than their unadapted counterparts. Toy hacks are also an opportunity to teach and practice engineering skills such as soldering and technical problem solving. Many resources are available online to assist makers with hosting toy hacks, but most of them lack information on holding the event. To fill this gap, the authors created a toy hack guide website, drawing from experience hosting two toy hacks. It walks users through steps like choosing the size of the event, the materials that need to be purchased, and connects them to other existing resources. In the future, it will be used to help people host more successful toy hacks.

Evolution has driven organisms to develop a wide range of biological mechanisms to protect against cancer. Some organisms, including the sponge Tethya wilhelma and the Placozoa Trichoplax adhaerens have developed particularly effective mechanisms to suppress cancer and repair DNA damage. While these mechanisms are rooted in DNA damage repair and prevention, evidence of bacteria may suggest that endosymbionts living within the organisms may plays a role as well. Likewise, other organisms, such as the flatworm Macrostomum lignano, are proven model organisms whose extensive documentation enables more in-depth analysis of biological mechanisms associated with cancer. Sponges, flatworms, and Placozoa were exposed to X-ray radiation totaling 600 Gy, 25 Gy, and up to 240 Gy, respectively. RNA sequencing and bioinformatics analyses were undergone to determine the differential gene expression of the animals at different time points. No common response to the X-ray radiation was discovered amongst all organisms. Instead, sponges showed evidence of tumor suppression and DNA repair gene upregulation including CUBN, bacterial endosymbionts showed evidence of lateral gene transfer and different DNA repair genes including FH, and flatworms showed evidence of allelic and mutational shifts in which tumorous populations became more reliant on alternate alleles and a single variant signature. This study highlights the varying mechanisms that have evolved in different organisms and the importance of studying these novel model organisms further.

An immune regulatory network was constructed for the purpose of identifying target regulators in malignant pleural mesothelioma for therapies. An identified causal flow linked a mutation of D-dopachrome tautomerase to a heightened expression of regulator ASH1L and consequent down regulation of chemokine CCL5 and invasion of CD8+ T cells. Experimental validation of this initial use case indicates mRNA expression of CCL5 within the tumor cells and subsequent protein expression and secretion. Further analyses will explore the migration of CD8+ T cells in response to the chemotactic CCL5.

During a joint ASU-Prescott College visit to the Maasai Mara in Kenya in June-July 2018, it became obvious that many Maasai women produce beadwork sold locally to help support their families. The difficulties they face include inconsistent sales due to lack of customers, lulls in tourism, and unfair competition. During this visit, the idea of selling the crafts online via Etsy was suggested. It received overwhelming support from the community through MERC, the The Maasai Education, Research and Conservation Institute.

Patients need to know current and available options for prosthetic devices. Devices are categorized depending on the region of amputation and their purpose. Retrospection on the history of prosthetic devices leading into modern ones allows for an interpretation of successes and necessary improvements moving forward. One promising avenue for prostheses is the development of neuroprostheses that much more closely resemble some of the functionality taken for granted in natural limbs. Proprioception, more commonly known as the ‘sixth sense’, would be a very desirable characteristic of these devices and is the subject of current research efforts. In the meantime, it is necessary to help patients evaluate what products are out there that identify more strongly with their individualized preferences.