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- Creators: School of Life Sciences
Description
For waste management in Asunción, Paraguay to improve, so too must the rate of public recycling participation. However, due to minimal public waste management infrastructure, it is up to individual citizens and the private sector to develop recycling solutions in the city. One social enterprise called Soluciones Ecológicas (SE) has deployed a system of drop-off recycling stations called ecopuntos, which allow residents to deposit their paper and cardboard, plastic, and aluminum. For SE to maximize the use of its ecopuntos, it must understand the perceived barriers to, and benefits of, their use. To identify these barriers and benefits, a doer on-doer survey based on the behavioral determinants outlined in the Designing for Behavior Change Framework was distributed among Asunción residents. Results showed that perceived self-efficacy, perceived social norms, and perceived positive consequences – as well as age – were influential in shaping ecopunto use. Other determinants such as perceived negative consequences, access, and universal motivators were significant predictors of gender and age. SE and other institutions looking to improve recycling can use these results to design effective behavior change interventions.
ContributorsLoPrete, Eric (Author) / Klinsky, Sonja (Contributor) / Fischer, Daniel (Contributor) / Wiek, Arnim (Contributor)
Created2020-04-24
Description
Multi-scalar, integrated and transformational solutions are necessary to address the complex problems of climate change and sustainable development. Cities are using urban living labs to develop and test such solutions; however, the pace of transformation does not yet match the urgency of the problems at hand. In business, accelerators are used to advance new and potentially transformational enterprises, giving fresh ideas an advantage over more established competition, thereby accelerating the pace of change. This article examines the accelerator model and considers its adaptation to urban living labs. From the literature, a multi-scalar business accelerator model is proposed that addresses both individual and system interventions to advance sustainability transformations. Also proposed is a formative-evaluation framework to guide effective implementation of the accelerator model. This article concludes with recommendations for scholars and practitioners working on urban living labs to utilize business accelerators to advance sustainability transformations.
ContributorsMack, Ashley (Author) / Whithycombe Keeler, Lauren (Contributor, Contributor) / Wiek, Arnim (Contributor) / von Wehrden, Henrik (Contributor)
Created2019-04-24
Description
Lipid microdomains play a vital role in a number of biological processes. They are often a target of diseases and viruses. Viruses in particular utilize lipid microdomains to gain entry and fuse with the host-cell membrane. Measles virus (MV) a human pathogen, spread from cell to cell by inducing fusion of cellular membranes. This causes the formation of large multinucleated cells, syncytia. It has been previously reported that lipid microdomains are essential for measles virus infection/replication. In this study we used methyl beta cyclodextrin (MBCD), a cholesterol-sequestering agent to disrupt lipid microdomains. Through transfection of Vero h/SLAM cells, we found that Measles virus fusion was dependent on lipid microdomains integrity. Indeed, a dose dependent fusion inhibition was documented with increasing concentrations of MBCD resulting in reduced formation of syncytia.
ContributorsKwan, Jason (Author) / Reyes del Valle, Jorge (Thesis director) / Chang, Yung (Committee member) / Mor, Tsafrir (Committee member) / Barrett, The Honors College (Contributor) / Department of Finance (Contributor) / School of Life Sciences (Contributor)
Created2013-05
Description
The Community Action Research Experiences (CARE) Program collaborated with the WellCare Foundation (WCF) to assess the referral sources of the clinic in order to more effectively reach additional potential patients. Archival data were analyzed from a 19-month period from the medical records of patients. Also, data were collected from interviews with the case manager of agencies that were a known referral source of WCF. These case manager interviews were completed over a one-month period. For the archival data part of the project, data were collected from 117 patients. Four representatives from community agencies participated in phone interviews. The results indicated that the most common referral sources were word of mouth, followed by community agency referrals. The results also indicated that WCF appears to have served a unique niche that is not served by other non-profit health clinics. These results led to implications for action and direction for future applied research.
ContributorsEbbing, Brittany Gabrielle (Author) / Spinrad, Tracy (Thesis director) / Dumka, Larry (Committee member) / Brougham, Jennifer (Committee member) / Barrett, The Honors College (Contributor) / T. Denny Sanford School of Social and Family Dynamics (Contributor) / School of Life Sciences (Contributor)
Created2013-05
Description
Abstract As we move forward in education reform in the globalized 21st century, the United States must visit new ways to teach science in high school classrooms. The goal of this investigation is to analyze the current research literature for the best and most promising teaching strategies and techniques in secondary education biology classrooms that promote academic excellence for all students. Looking at policy and school reform literature in science education to establish the context of the current system, the paper will not focus on the political as or systematic changes needed to ground an overall successful system. However, because of their inherent effect on the education system, the political aspects of education reform will be briefly addressed. The primary focus, by addressing the emphasis on standardization, inflexibility of instruction and lack of creativity specifically in high school biology classrooms, seeks to clarify small changes that can influence students' academic outcomes. The United States is performing on such a poor level in science and math proficiency that it cannot match students abroad and this is seen through test scores and the production of competent graduates. This investigation serves to organize literature from education researchers and showcase best and promising teaching and learning practices that catalyze academic excellence for all students in our pluralistic, democratic and complex schooling and societal contexts.
ContributorsHildebrandt, Kevin Andrew (Author) / Ovando, Carlos (Thesis director) / Schugurensky, Daniel, 1958- (Committee member) / Fischman, Gustavo (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / School of International Letters and Cultures (Contributor)
Created2013-05
Description
Previous findings from our lab have demonstrated that nicotine and social reward have synergistic effects when experienced together versus when experienced separately. The purpose of this experiment is to understand the neural mechanisms underlying this synergistic effect by quantifying Fos protein, a marker for neural activation, in various brain regions. We utilized the conditioning place preference (CPP) model to assess reward. Four groups of adolescent male rats (n=120) were given either nicotine (Nic) (0.1 mg/kg/mL) or saline (Sal) and were placed in the CPP apparatus either with a social partner (Soc) or alone (Iso). Thus, groups were: 1.)Sal+Iso, 2).Sal+Soc, 3).Nic+Iso, 4).Nic+Soc. Brains of some the rats (n=40) were collected for Fos staining 90 minutes after the last conditioning session to obtain Fos data in response to direct exposure to the stimuli. The following regions were analyzed for Fos expression: central amygdala (CeA), medial amygdala (MeA), basolateral amygdala (BLA), nucleus accumbens core (NAcCore), and nucleus accumbens shell (NAcShell). Place preference changes occurred in socially-conditioned groups reflecting social reward and in nicotine-conditioned groups reflecting nicotine reward. As expected, the Sal+Iso control group failed to display a preference change. Fos data revealed a significant increase in Fos expression in the CeA, MeA, NAcCore and NAcShell for socially-conditioned animals and a significant decrease in the NAcCore for nicotine-conditioned groups. Experiencing both social and nicotine rewards together appeared to produce greater activation in the BLA. However, there was an increase in Fos expression in the negative control group relative to Nic+Iso group. The results of CPP suggest that social, nicotine and their combination are rewarding. The combination of the nicotine and social reward could have been more rewarding than social and nicotine separately, but the test was not sensitive to reward magnitude. The increase in Fos expression in the negative control group in the BLA could be due to isolation stress. Overall, these results suggest that these brain regions had greater activation to social reward.
ContributorsGoenaga, Julianna Gloria (Author) / Neisewander, Janet (Thesis director) / Orchinik, Miles (Committee member) / Olive, Michael (Committee member) / Barrett, The Honors College (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor) / School of Life Sciences (Contributor)
Created2013-05
Description
Many of the derived features of the human skeleton can be divided into two adaptive suites: traits related to bipedalism and traits related to encephalization. The cervical spine connects these adaptive suites and is itself unique in its marked lordosis. I approach human cervical evolution from three directions: the functional significance of cervical curvature, the identification of cervical lordosis in osteological material, and the representation of the cervical spine in the hominin fossil record.
ContributorsFatica, Lawrence Martin (Author) / Kimbel, William (Thesis director) / Reed, Kaye (Committee member) / Schwartz, Gary (Committee member) / Barrett, The Honors College (Contributor) / School of Human Evolution and Social Change (Contributor) / School of Life Sciences (Contributor)
Created2014-05
Description
It is well known that deficiencies in key chemical elements (such as phosphorus, P) can reduce animal growth; however, recent empirical data have shown that high levels of dietary nutrients can also reduce animal growth. In ecological stoichiometry, this phenomenon is known as the "stoichiometric knife edge," but its underlying mechanisms are not well-known. Previous work has suggested that the crustacean zooplankter Daphnia reduces its feeding rates on phosphorus-rich food, causing low growth due to insufficient C (energy) intake. To test for this mechanism, feeding rates of Daphnia magna on algae (Scenedesmus acutus) differing in C:P ratio (P content) were determined. Overall, there was a significant difference among all treatments for feeding rate (p < 0.05) with generally higher feeding rates on P-rich algae. These data indicate that both high and low food C:P ratio do affect Daphnia feeding rate but are in contradiction with previous work that showed that P-rich food led to strong reductions in feeding rate. Additional experiments are needed to gain further insights.
ContributorsSchimpp, Sarah Ann (Author) / Elser, James (Thesis director) / Neuer, Susanne (Committee member) / Peace, Angela (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / School of Sustainability (Contributor)
Created2014-05
Description
The next generation will be better prepared to cope with the daunting sustainability challenges if education for sustainable development is being taught and learned across educational sectors. K-12 school education will play a pivotal role in this process, most prominently, the teachers serving at these schools. While pre-service teachers’ education will contribute to this transition, success will depend on effective professional development in sustainability education to teachers currently in service. Arizona State University has pioneered the development and delivery of such a programme. We present the design principles, the programme, and insights from its initial applications that involved 246 K-12 in-service teachers from across the USA. The evaluation results indicate that due to participation in the programme, sustainability knowledge, perception of self-efficacy, inclusion of sustainability in the classroom, modelling of sustainable behaviours, and linking action to content all increased. We conclude with recommendations for the widespread adopting of the programme.
ContributorsRedman, Erin (Author) / Redman, Aaron (Author) / Wiek, Arnim (Author)
Created2018-07-13
Description
Background
The maintenance of chromosomal integrity is an essential task of every living organism and cellular repair mechanisms exist to guard against insults to DNA. Given the importance of this process, it is expected that DNA repair proteins would be evolutionarily conserved, exhibiting very minimal sequence change over time. However, BRCA1, an essential gene involved in DNA repair, has been reported to be evolving rapidly despite the fact that many protein-altering mutations within this gene convey a significantly elevated risk for breast and ovarian cancers.
Results
To obtain a deeper understanding of the evolutionary trajectory of BRCA1, we analyzed complete BRCA1 gene sequences from 23 primate species. We show that specific amino acid sites have experienced repeated selection for amino acid replacement over primate evolution. This selection has been focused specifically on humans and our closest living relatives, chimpanzees (Pan troglodytes) and bonobos (Pan paniscus). After examining BRCA1 polymorphisms in 7 bonobo, 44 chimpanzee, and 44 rhesus macaque (Macaca mulatta) individuals, we find considerable variation within each of these species and evidence for recent selection in chimpanzee populations. Finally, we also sequenced and analyzed BRCA2 from 24 primate species and find that this gene has also evolved under positive selection.
Conclusions
While mutations leading to truncated forms of BRCA1 are clearly linked to cancer phenotypes in humans, there is also an underlying selective pressure in favor of amino acid-altering substitutions in this gene. A hypothesis where viruses are the drivers of this natural selection is discussed.
The maintenance of chromosomal integrity is an essential task of every living organism and cellular repair mechanisms exist to guard against insults to DNA. Given the importance of this process, it is expected that DNA repair proteins would be evolutionarily conserved, exhibiting very minimal sequence change over time. However, BRCA1, an essential gene involved in DNA repair, has been reported to be evolving rapidly despite the fact that many protein-altering mutations within this gene convey a significantly elevated risk for breast and ovarian cancers.
Results
To obtain a deeper understanding of the evolutionary trajectory of BRCA1, we analyzed complete BRCA1 gene sequences from 23 primate species. We show that specific amino acid sites have experienced repeated selection for amino acid replacement over primate evolution. This selection has been focused specifically on humans and our closest living relatives, chimpanzees (Pan troglodytes) and bonobos (Pan paniscus). After examining BRCA1 polymorphisms in 7 bonobo, 44 chimpanzee, and 44 rhesus macaque (Macaca mulatta) individuals, we find considerable variation within each of these species and evidence for recent selection in chimpanzee populations. Finally, we also sequenced and analyzed BRCA2 from 24 primate species and find that this gene has also evolved under positive selection.
Conclusions
While mutations leading to truncated forms of BRCA1 are clearly linked to cancer phenotypes in humans, there is also an underlying selective pressure in favor of amino acid-altering substitutions in this gene. A hypothesis where viruses are the drivers of this natural selection is discussed.
ContributorsLou, Dianne I. (Author) / McBee, Ross M. (Author) / Le, Uyen Q. (Author) / Stone, Anne (Author) / Wilkerson, Gregory K. (Author) / Demogines, Ann M. (Author) / Sawyer, Sara L. (Author) / College of Liberal Arts and Sciences (Contributor) / School of Human Evolution and Social Change (Contributor) / School of Life Sciences (Contributor)
Created2014-07-11