Matching Items (271)
Description
Many of the derived features of the human skeleton can be divided into two adaptive suites: traits related to bipedalism and traits related to encephalization. The cervical spine connects these adaptive suites and is itself unique in its marked lordosis. I approach human cervical evolution from three directions: the functional significance of cervical curvature, the identification of cervical lordosis in osteological material, and the representation of the cervical spine in the hominin fossil record.
ContributorsFatica, Lawrence Martin (Author) / Kimbel, William (Thesis director) / Reed, Kaye (Committee member) / Schwartz, Gary (Committee member) / Barrett, The Honors College (Contributor) / School of Human Evolution and Social Change (Contributor) / School of Life Sciences (Contributor)
Created2014-05
Description
Background
The transmission dynamics of Tuberculosis (TB) involve complex epidemiological and socio-economical interactions between individuals living in highly distinct regional conditions. The level of exogenous reinfection and first time infection rates within high-incidence settings may influence the impact of control programs on TB prevalence. The impact that effective population size and the distribution of individuals’ residence times in different patches have on TB transmission and control are studied using selected scenarios where risk is defined by the estimated or perceive first time infection and/or exogenous re-infection rates.
Methods
This study aims at enhancing the understanding of TB dynamics, within simplified, two patch, risk-defined environments, in the presence of short term mobility and variations in reinfection and infection rates via a mathematical model. The modeling framework captures the role of individuals’ ‘daily’ dynamics within and between places of residency, work or business via the average proportion of time spent in residence and as visitors to TB-risk environments (patches). As a result, the effective population size of Patch i (home of i-residents) at time t must account for visitors and residents of Patch i, at time t.
Results
The study identifies critical social behaviors mechanisms that can facilitate or eliminate TB infection in vulnerable populations. The results suggest that short-term mobility between heterogeneous patches contributes to significant overall increases in TB prevalence when risk is considered only in terms of direct new infection transmission, compared to the effect of exogenous reinfection. Although, the role of exogenous reinfection increases the risk that come from large movement of individuals, due to catastrophes or conflict, to TB-free areas.
Conclusions
The study highlights that allowing infected individuals to move from high to low TB prevalence areas (for example via the sharing of treatment and isolation facilities) may lead to a reduction in the total TB prevalence in the overall population. The higher the population size heterogeneity between distinct risk patches, the larger the benefit (low overall prevalence) under the same “traveling” patterns. Policies need to account for population specific factors (such as risks that are inherent with high levels of migration, local and regional mobility patterns, and first time infection rates) in order to be long lasting, effective and results in low number of drug resistant cases.
The transmission dynamics of Tuberculosis (TB) involve complex epidemiological and socio-economical interactions between individuals living in highly distinct regional conditions. The level of exogenous reinfection and first time infection rates within high-incidence settings may influence the impact of control programs on TB prevalence. The impact that effective population size and the distribution of individuals’ residence times in different patches have on TB transmission and control are studied using selected scenarios where risk is defined by the estimated or perceive first time infection and/or exogenous re-infection rates.
Methods
This study aims at enhancing the understanding of TB dynamics, within simplified, two patch, risk-defined environments, in the presence of short term mobility and variations in reinfection and infection rates via a mathematical model. The modeling framework captures the role of individuals’ ‘daily’ dynamics within and between places of residency, work or business via the average proportion of time spent in residence and as visitors to TB-risk environments (patches). As a result, the effective population size of Patch i (home of i-residents) at time t must account for visitors and residents of Patch i, at time t.
Results
The study identifies critical social behaviors mechanisms that can facilitate or eliminate TB infection in vulnerable populations. The results suggest that short-term mobility between heterogeneous patches contributes to significant overall increases in TB prevalence when risk is considered only in terms of direct new infection transmission, compared to the effect of exogenous reinfection. Although, the role of exogenous reinfection increases the risk that come from large movement of individuals, due to catastrophes or conflict, to TB-free areas.
Conclusions
The study highlights that allowing infected individuals to move from high to low TB prevalence areas (for example via the sharing of treatment and isolation facilities) may lead to a reduction in the total TB prevalence in the overall population. The higher the population size heterogeneity between distinct risk patches, the larger the benefit (low overall prevalence) under the same “traveling” patterns. Policies need to account for population specific factors (such as risks that are inherent with high levels of migration, local and regional mobility patterns, and first time infection rates) in order to be long lasting, effective and results in low number of drug resistant cases.
ContributorsMoreno Martinez, Victor (Author) / Espinoza Cortes, Baltazar (Author) / Barley, Kamal (Author) / Paredes Gutierrez, Marlio (Author) / Bichara, Derdei (Author) / Mubayi, Anuj (Author) / Castillo-Chavez, Carlos (Author) / Simon M. Levin Mathematical, Computational and Modeling Sciences Center (Contributor) / College of Liberal Arts and Sciences (Contributor) / School of Human Evolution and Social Change (Contributor)
Created2017-01-11
Description
Background
The maintenance of chromosomal integrity is an essential task of every living organism and cellular repair mechanisms exist to guard against insults to DNA. Given the importance of this process, it is expected that DNA repair proteins would be evolutionarily conserved, exhibiting very minimal sequence change over time. However, BRCA1, an essential gene involved in DNA repair, has been reported to be evolving rapidly despite the fact that many protein-altering mutations within this gene convey a significantly elevated risk for breast and ovarian cancers.
Results
To obtain a deeper understanding of the evolutionary trajectory of BRCA1, we analyzed complete BRCA1 gene sequences from 23 primate species. We show that specific amino acid sites have experienced repeated selection for amino acid replacement over primate evolution. This selection has been focused specifically on humans and our closest living relatives, chimpanzees (Pan troglodytes) and bonobos (Pan paniscus). After examining BRCA1 polymorphisms in 7 bonobo, 44 chimpanzee, and 44 rhesus macaque (Macaca mulatta) individuals, we find considerable variation within each of these species and evidence for recent selection in chimpanzee populations. Finally, we also sequenced and analyzed BRCA2 from 24 primate species and find that this gene has also evolved under positive selection.
Conclusions
While mutations leading to truncated forms of BRCA1 are clearly linked to cancer phenotypes in humans, there is also an underlying selective pressure in favor of amino acid-altering substitutions in this gene. A hypothesis where viruses are the drivers of this natural selection is discussed.
The maintenance of chromosomal integrity is an essential task of every living organism and cellular repair mechanisms exist to guard against insults to DNA. Given the importance of this process, it is expected that DNA repair proteins would be evolutionarily conserved, exhibiting very minimal sequence change over time. However, BRCA1, an essential gene involved in DNA repair, has been reported to be evolving rapidly despite the fact that many protein-altering mutations within this gene convey a significantly elevated risk for breast and ovarian cancers.
Results
To obtain a deeper understanding of the evolutionary trajectory of BRCA1, we analyzed complete BRCA1 gene sequences from 23 primate species. We show that specific amino acid sites have experienced repeated selection for amino acid replacement over primate evolution. This selection has been focused specifically on humans and our closest living relatives, chimpanzees (Pan troglodytes) and bonobos (Pan paniscus). After examining BRCA1 polymorphisms in 7 bonobo, 44 chimpanzee, and 44 rhesus macaque (Macaca mulatta) individuals, we find considerable variation within each of these species and evidence for recent selection in chimpanzee populations. Finally, we also sequenced and analyzed BRCA2 from 24 primate species and find that this gene has also evolved under positive selection.
Conclusions
While mutations leading to truncated forms of BRCA1 are clearly linked to cancer phenotypes in humans, there is also an underlying selective pressure in favor of amino acid-altering substitutions in this gene. A hypothesis where viruses are the drivers of this natural selection is discussed.
ContributorsLou, Dianne I. (Author) / McBee, Ross M. (Author) / Le, Uyen Q. (Author) / Stone, Anne (Author) / Wilkerson, Gregory K. (Author) / Demogines, Ann M. (Author) / Sawyer, Sara L. (Author) / College of Liberal Arts and Sciences (Contributor) / School of Human Evolution and Social Change (Contributor) / School of Life Sciences (Contributor)
Created2014-07-11
Description
Eat Drink Smoke is an illustrated journal/memoir about trauma, addiction and mental illness. It is a creative project wherein storytelling is used as therapy.
ContributorsGoldberg, Hannah (Author) / Soares, Rebecca (Thesis director) / Dombrowski, Rosemarie (Committee member) / School of Social Work (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
Menstruation has been characterized as powerful, magical, and mysterious. Historically, it was believed menstrual blood could cure leprosy, warts, birthmarks, gout, goiter, hemorrhoids, epilepsy, worms, and headaches. Menstrual blood was used as a love charm and as a means to ward off river demons or evil spirits, and could be used to honor a god (DeLaney, Lupton, & Toth, 1988, pp.8-9). Contemporary studies reveal that women around the world continue to celebrate their power to create. The World Health Organization studied attitudes of women of all socioeconomic classes in 10 countries (Egypt, India, Indonesia, Jamaica, Pakistan, Philippines, United Kingdom, United States, Yugoslavia, Mexico, Korea) and found that most women saw menstruation as a positive event (DeLaney et al., 1988, p. 14). In a similar study, Mexican-American women perceived menstruation positively, as a process that "cleans" the body (DeLaney et al., 1988, p. 14).
ContributorsAzmat, Alia (Author) / Burleson, Mary (Thesis director) / Roberts, Nicole (Committee member) / Trevathan, Wenda (Committee member) / Barrett, The Honors College (Contributor) / School of Human Evolution and Social Change (Contributor)
Created2012-12
Description
The objective of this DAPT research is to understand: (1) what the benefits of creating a DAPT are by analyzing what asset protections are provided, depending on the governing state; and (2) what ethical and legal concerns are presented with varying DAPT statutory schemes that ought to be considered by (a) the states enacting these laws; and (b) individuals who are establishing their own DAPTs. In general, it can be determined that the main benefit of creating a DAPT is the asset protection provided and its potential dissuasion of creditors pursuing litigation. During examination of the differing DAPT statutory schemes in the first chapter, it becomes evident that some states provide for more asset protections than exceptions to such, creating both legal and ethical concerns. The second chapter discusses the potential legal and ethical complications that DAPTs present by reviewing and analyzing current case law. These complications include the improper application of legislation, divorce, child support, creation to avoid current known claims, loan securitization, bankruptcy, crossing legal jurisdictions, and trust law changes and amendments. Chapter 3 then uses the potential complications to urge states to reflect on their moral duties when establishing DAPT legislation and encourages individuals to review the consequences they may have when creating a DAPT based on their personal situation. Concludingly, a DAPT is a helpful asset protection tool. However, legislation ought to have a set standard for exclusions from protection for division of marital assets, child support claims, creation of and transfers to a DAPT in an attempt to deprive active known creditors from collecting on their rightful judgements, loan securitization, and state and federal government claims.
ContributorsSutherland, Kendra (Author) / Sturgess, Jessica (Thesis director) / Crampton, Liz (Committee member) / Frazier, Grant (Committee member) / Barrett, The Honors College (Contributor) / School of Social Work (Contributor)
Created2022-05
Description
I conducted an oral history project of five women with journeys in the Christian faith who had experience working with asylum seekers and refugees in the Phoenix metropolitan area. I explore with this project the perceptions of the helping relationship through the stories of these women and how their beliefs about their faith and work inform each other to pursue meaningful connections for the benefit of others.
ContributorsSchroeder, Kirsten (Author) / O'Flaherty, Katherine (Thesis director) / Sarat, Leah (Committee member) / Barrett, The Honors College (Contributor) / School of Humanities, Arts, and Cultural Studies (Contributor) / School of Social Work (Contributor)
Created2022-05
Description
The importance of social work lies in the ability of individuals, families, and communities to thrive. It is important to note that social work encompasses a wide range of professions. However, this creative project will examine its different dimensions, specifically within the field of criminal justice. The purpose of this thesis project is to promote social work as a profession and explore its growing impact on the criminal justice system. As part of this effort, it is also intended to dispel the myth that social workers work exclusively in child protection agencies. Viewers will be introduced to exciting opportunities for meaningful change at the emerging intersection of social work and criminal justice, which is becoming increasingly prevalent in American society. This project will also highlight how negative media (news and documentaries like Gabriel Fernandez on Netflix) about social workers employed in the DCS system do not accurately portray current circumstances. This will be accomplished through a short video/documentary-style project that interviews social workers and social service workers employed in the criminal justice field. An interview will consist of questions designed to dispel myths about social workers and promote the diversity of the profession. The purpose of this is to provide an ‘on-the-ground’ perspective of real opportunities in the community, including descriptions of various occupations and the mission of agencies that employ at the cross-section of social work and criminal justice. This is done to enhance the viewers' perception of the field and give them the opportunity to experience real-life situations.
ContributorsSosa, Jessica (Author) / England, Alison (Thesis director) / Roe-Sepowitz, Dominique (Committee member) / Barrett, The Honors College (Contributor) / School of Social Work (Contributor) / School of Criminology and Criminal Justice (Contributor)
Created2024-05
Description
Within the realm of parenting, there is research about a distinct stage entitled emerging adulthood that encompasses biopsychosocial development between the ages of 18 and 25. The research study seeks to answer the questions: how do current parenting practices influence emerging adult mental health, and what adjustments must be made to improve upon these relationships? Past studies have demonstrated that there is a relationship between the developmental period of emerging adulthood, which is characterized by identity formation itself, and the mental health of both emerging adults and their parents. However, upon reviewing the literature on emerging adulthood, it was revealed that there is a gap in regard to how to parent adult children and foster a positive relationship. While the goal is to explore this gap, the research team is additionally seeking to utilize new information to create a parenting course that promotes positive adjustments to the current relationship between emerging adults and their parents. To explore this, the research team conducted emerging adult surveys, asking participants to analyze their current connection with their parents' practices and the effects they have on their mental health. Additionally, surveys and interviews were done with Licensed Clinical Social Workers (LCSWs) to bolster the evidence-based methods that this population uses to support emerging adults.
ContributorsBrobak, Rachel (Author) / Golden, Ariella (Co-author) / Jensen, Kimberly (Thesis director) / Evans, Amanda (Committee member) / Barrett, The Honors College (Contributor) / School of Social Work (Contributor) / Sanford School of Social and Family Dynamics (Contributor)
Created2024-05
Description
This project compiles data and research about the impact that reporting on traumatic events and negative feedback/backlash has on journalists' mental health. Compiled into an online blog, there are also concrete models and outlines that are formatted for both newsrooms and journalism schools to help support against the tolls these topics can take on journalists' mental health.
ContributorsKobley, Lauren (Author) / Rodriguez, Rick (Thesis director) / Rosequist, Melissa (Committee member) / Barrett, The Honors College (Contributor) / School of Social Work (Contributor) / Walter Cronkite School of Journalism and Mass Comm (Contributor)
Created2023-05