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Description
The goal of the studies described in this thesis was to determine the changes in vascular density in the paraventricular nucleus (PVN) of the hypothalamus following prenatal exposure to the synthetic glucocorticoid hormone, dexamethasone (DEX). DEX is a synthetic glucocorticoid used clinically in women at risk for preterm delivery or in preterm infants to promote proper pulmonary development in high-risk neonates. Prenatal exposure to glucocorticoids such as DEX may change the development of important brain regulatory centers such as the PVN, resulting in increased risk for diseases in adulthood.
Previous studies have demonstrated that the hypothalamus regulates neuroendocrine and autonomic function and behavior. Within the hypothalamus, the paraventricular nucleus (PVN) is an integratory node that contains neurons associated with the control of neuroendocrine and autonomic responses. The PVN also has one of the highest density of blood vessels within the brain. Alterations of normal PVN angiogenesis by dexamethasone could potentially result in long-term modifications of brain and endocrine functions.
Timed-pregnant Sprague Dawley female rats received DEX on gestational days 18-21 and the resulting progeny were sacrificed at Postnatal Day (PND) 0, 4, 14, and 21. A tomato lectin, Lycopersicon Esculentum labeled with DyLight594 was used to stain blood vessels in the PVN and scanning confocal microscopy was used to analyze the experimental brains for PVN blood vessel density
Analysis of data using a 3-way analysis of variance (ANOVA) with age, sex and treatment as main factors, showed a significant age effect in vascular density. Analysis of female data by 2-way ANOVA demonstrated a significant effect of age, but no treatment or interaction effects. Post-hoc analysis shows significant differences at PND 2, 4, 14, and 21 compared to PND0. A Student‘s t-test of a planned comparison on PND2 showed a significant reduction by DEX treatment (p < 0.05). Analysis of data from females, using 2-way ANOVA demonstrated a significant effect of age, but no treatment or interaction effects. Post-hoc analysis shows significant differences at PND 2, 4, 14, and 21 compared to PND0. A planned comparison at PND 2 using Student’s t-test indicated a significant reduction by dex treatment.
The results of these studies demonstrate that there is significant postnatal angiogenic programming and that the vascular density of the PVN is altered by prenatal dexamethasone administration at PND2. The time-course shows developmental fluctuations in vessel density that may prove to be physiologically significant for normal brain function and developmental programming of brain and behavior.
Previous studies have demonstrated that the hypothalamus regulates neuroendocrine and autonomic function and behavior. Within the hypothalamus, the paraventricular nucleus (PVN) is an integratory node that contains neurons associated with the control of neuroendocrine and autonomic responses. The PVN also has one of the highest density of blood vessels within the brain. Alterations of normal PVN angiogenesis by dexamethasone could potentially result in long-term modifications of brain and endocrine functions.
Timed-pregnant Sprague Dawley female rats received DEX on gestational days 18-21 and the resulting progeny were sacrificed at Postnatal Day (PND) 0, 4, 14, and 21. A tomato lectin, Lycopersicon Esculentum labeled with DyLight594 was used to stain blood vessels in the PVN and scanning confocal microscopy was used to analyze the experimental brains for PVN blood vessel density
Analysis of data using a 3-way analysis of variance (ANOVA) with age, sex and treatment as main factors, showed a significant age effect in vascular density. Analysis of female data by 2-way ANOVA demonstrated a significant effect of age, but no treatment or interaction effects. Post-hoc analysis shows significant differences at PND 2, 4, 14, and 21 compared to PND0. A Student‘s t-test of a planned comparison on PND2 showed a significant reduction by DEX treatment (p < 0.05). Analysis of data from females, using 2-way ANOVA demonstrated a significant effect of age, but no treatment or interaction effects. Post-hoc analysis shows significant differences at PND 2, 4, 14, and 21 compared to PND0. A planned comparison at PND 2 using Student’s t-test indicated a significant reduction by dex treatment.
The results of these studies demonstrate that there is significant postnatal angiogenic programming and that the vascular density of the PVN is altered by prenatal dexamethasone administration at PND2. The time-course shows developmental fluctuations in vessel density that may prove to be physiologically significant for normal brain function and developmental programming of brain and behavior.
ContributorsWidener, Andrew John-Claude (Author) / Handa, Robert (Thesis director) / Orchinik, Miles (Committee member) / Mustard, Julie (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor)
Created2014-05
Description
This thesis explores how motherhood as a status and social identity influences the help-seeking decisions made by women who experience Intimate Partner Violence (IPV) and enter a domestic violence shelter in Arizona. Specifically, this report examines the types, severity, and frequency of violence experienced by women with children and the methods of help-seeking among women without children and women with children. Special attention is paid to women who cite their children as a primary reason for seeking legal intervention and those who cite their children as a primary reason for not seeking legal intervention in their relationships. For the purposes of this study, a survey investigating the types and severity of violence experienced, the help-seeking practices of, and the safety-planning measures taken by IPV survivors was distributed to over 600 women in emergency domestic violence shelters in the Phoenix, Arizona area. Data from both closed- and open-ended questions asked on the survey is analyzed in the context of a review of existing literature on the subject and of current Arizona state-level policies and legislation. Conclusions focus on how the surveyed women's status as mothers related to the specific variables of their victimization and the help-seeking methods they used to achieve safety, and how state-level legislation reacts and acts as a barrier to certain types of help-seeking behaviors.
ContributorsHutchinson, Kimberley Robyn (Author) / Durfee, Alesha (Thesis director) / Messing, Jill Theresa (Committee member) / Barrett, The Honors College (Contributor) / School of Social Transformation (Contributor) / Department of English (Contributor)
Created2014-05
Description
Many of the derived features of the human skeleton can be divided into two adaptive suites: traits related to bipedalism and traits related to encephalization. The cervical spine connects these adaptive suites and is itself unique in its marked lordosis. I approach human cervical evolution from three directions: the functional significance of cervical curvature, the identification of cervical lordosis in osteological material, and the representation of the cervical spine in the hominin fossil record.
ContributorsFatica, Lawrence Martin (Author) / Kimbel, William (Thesis director) / Reed, Kaye (Committee member) / Schwartz, Gary (Committee member) / Barrett, The Honors College (Contributor) / School of Human Evolution and Social Change (Contributor) / School of Life Sciences (Contributor)
Created2014-05
Description
This paper takes a look at developing a technological start up revolving around the world of health and fitness. The entire process is documented, starting from the ideation phase, and continuing on to product testing and market research. The research done focuses on identifying a target market for a 24/7 fitness service that connects clients with personal trainers. It is a good study on the steps needed in creating a business, and serves as a learning tool for how to bring a product to market.
ContributorsHeck, Kyle (Co-author) / Mitchell, Jake (Co-author) / Korczynski, Brian (Co-author) / Peck, Sidnee (Thesis director) / Eaton, John (Committee member) / Barrett, The Honors College (Contributor) / Department of Finance (Contributor) / Department of Economics (Contributor) / Department of Management (Contributor) / Department of Psychology (Contributor) / Department of Supply Chain Management (Contributor) / School of Accountancy (Contributor) / W. P. Carey School of Business (Contributor)
Created2014-05
Description
This project is an investigation into the many financial issues professional athletes face. These issues include bad spending habits, poor investments, freeloaders (posses/entourages), and more. Following is an explanation of Financial Planning and Wealth Management, and how the application of these strategies and tactics - specifically the use of Sustainable Withdrawal Rates in a Capital Sufficiency Analysis - can help to avoid such issues. An illustration of these practices "in action" is given through a case study of fictional athletes and portfolios. Lastly, recommendations are given on potential solutions that could help prevent these problems from affecting more athletes.
ContributorsCastellani, Robert Thomas (Author) / Eaton, John (Thesis director) / Cassidy, Nancy (Committee member) / Judge, Evan (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / WPC Graduate Programs (Contributor) / W. P. Carey School of Business (Contributor) / School of Accountancy (Contributor)
Created2014-05
Description
This correlational study investigated how adolescent's artistic style changed depending on their level of interest in art. The participants were 28 students from the 7th and 8th grade of Zuni Hills Elementary School. A survey was administered which measured, in regards to their artwork, the categories of interest, experimentation in subject, experimentation in material, abstract style, literal style, imagination, identity, emotion and storytelling. It was predicted that interest would have a significant positive relationship with abstract style and experimentation with subject. It was also predicted that interest would have a significant negative relationship with literal style and experimentation with material. Scores for all categories were compared and significant positive relations were found in regards to emotion, identity and storytelling. There was also a significant positive realtionship between interest and imagination as well as interest and emotion. These findings add to research about motivation in adolescent art through the means of expression of the self.
ContributorsAbeyta, Jennifer Lee (Author) / Miller, Paul (Thesis director) / Lewis, Stephen K. (Committee member) / Barrett, The Honors College (Contributor) / School of Social and Behavioral Sciences (Contributor)
Created2014-05
Description
This thesis discusses the court-martial of Army Captain Rogelio "Roger" Maynulet and the public reaction to the trial. Maynulet's court-martial took place in 2005 for the mercy killing of an Iraqi during his deployment in 2004. While in pursuit of Muqtada al-Sadr, who was considered a high value target, Maynulet killed the driver of the car which intelligence said al-Sadr was a passenger. Maynulet was convicted of voluntary manslaughter and dismissed from the military. The goal of this research is to show Maynulet was rightly convicted and delve into how public reaction reveals varied and divisive opinions toward mercy killing and military behavior.
ContributorsTindell, Yvonne Sandra (Author) / Simpson, Brooks (Thesis director) / Lynk, Myles (Committee member) / Barrett, The Honors College (Contributor) / School of Politics and Global Studies (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor)
Created2014-05
Description
It is well known that deficiencies in key chemical elements (such as phosphorus, P) can reduce animal growth; however, recent empirical data have shown that high levels of dietary nutrients can also reduce animal growth. In ecological stoichiometry, this phenomenon is known as the "stoichiometric knife edge," but its underlying mechanisms are not well-known. Previous work has suggested that the crustacean zooplankter Daphnia reduces its feeding rates on phosphorus-rich food, causing low growth due to insufficient C (energy) intake. To test for this mechanism, feeding rates of Daphnia magna on algae (Scenedesmus acutus) differing in C:P ratio (P content) were determined. Overall, there was a significant difference among all treatments for feeding rate (p < 0.05) with generally higher feeding rates on P-rich algae. These data indicate that both high and low food C:P ratio do affect Daphnia feeding rate but are in contradiction with previous work that showed that P-rich food led to strong reductions in feeding rate. Additional experiments are needed to gain further insights.
ContributorsSchimpp, Sarah Ann (Author) / Elser, James (Thesis director) / Neuer, Susanne (Committee member) / Peace, Angela (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / School of Sustainability (Contributor)
Created2014-05
Description
In recent years, China and Japan have both experienced the serious challenge of handling some of the most destructive natural disasters in human history with the 2008 Wenchuan earthquake and the 2011 Fukushima incident. After careful examination of geological surveys and further evidence released in the aftermath, these two incidents can be regarded as man-made or technological disasters, which differentiate them from the multitude of natural disasters that have happened previously. Their unique causation also creates a need for separate analysis of the public reaction towards these disasters. Due to existing knowledge and communication gaps within the Chinese and Japanese governments, the official media reports of these disasters also hold many problems, such as a lack of clarity, consistency, and transparency caused by a shortage of investigative journalism. Japan, in particular, has grappled with the bias of "nuclear nationalism" since post-World War II. These issues and ideas can change public opinion drastically, which makes it necessary to evaluate the combined effects on the psychology of people trying to come to terms with these technological disasters and examine possible solutions for this problem.
ContributorsPaschke, Lauren Anne (Author) / Spring, Madeline (Thesis director) / Zhu, Jie (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor)
Created2014-05
Description
For many years, the countries of Sub-Saharan Africa, like many other unindustrialized nations, followed the internally-oriented import substitution policies developed by theoreticians like Raul Prebisch. These measures were meant to force nations to develop their industrial capabilities in isolation from the rest of the world. However, these policies did little to improve the economy of many emerging countries. It was not until Asian countries switched to externally-oriented strategies that progress was made in their developing economies. In the early 1980s, a "Washington Consensus" was practiced that included a trade provision for the opening of emerging markets. Since then, many Sub-Saharan African nations have implemented policies that have opened up their markets to the rest of the world. However, most of these countries have not realized the benefits typically ascribed to open trade, causing some economists to doubt the economic growth benefits of trade liberalization. This thesis examines the connection between trade liberalization in Sub-Saharan Africa to review the consequences of recent trade reforms on the region's development and to identify some of the factors which contributed to individual countries successfully, or unsuccessfully, implementing trade liberalizing policies. It finds that the relationship between economic growth and trade liberalization is not as important as other growth factors and that there are multiple paths toward economic development.
ContributorsDussik, Jonathan Abraham DeBlock (Author) / DeSerpa, Allan (Thesis director) / Hill, John (Committee member) / Barrett, The Honors College (Contributor) / Department of Finance (Contributor) / Department of Economics (Contributor)
Created2014-12